枣仁安神颗粒联合阿普唑仑治疗老年失眠症合并焦虑抑郁的疗效及安全性分析  

Efficacy and safety of zaoren anshen keli combined with alprazolam in the treatment of elderly patients with insomnia complicated by anxiety and depression

作　　者：任健波 胡艳海 郁波 REN Jian-bo;HU Yan-hai;YU Bo(Department of General Medical,Hengxi Branch of Medical Community of People's Hospital Affiliated to Ningbo University,Zhejiang Ningbo 315131,China)

机构地区：[1]宁波大学附属人民医院医共体横溪分院全科,浙江宁波315131

出　　处：《临床药物治疗杂志》2022年第11期27-30,共4页Clinical Medication Journal

摘　　要：目的探讨枣仁安神颗粒联合阿普唑仑治疗老年失眠症合并焦虑抑郁的疗效及安全性。方法选取2018年7月1日至2021年7月31日期间宁波大学附属人民医院医共体横溪分院收治的100例老年失眠症合并焦虑抑郁患者,按随机数字表法分为对照组(n=50)和观察组(n=50)。对照组给予阿普唑仑,观察组在对照组的基础上给予枣仁安神颗粒。比较两组患者焦虑自评量表(SAS)、抑郁自评量表(SDS)、匹兹堡睡眠质量指数量表(PSQI)评分、生活质量及不良反应发生情况。结果治疗后,两组患者SAS评分平均值分别为(44.05±2.78)分和(52.38±2.62)分,SDS评分平均值分别为(44.07±1.59)分和(47.26±1.64)分。与治疗前相比,两组患者治疗后SAS及SDS评分均显著降低(均P<0.05),且观察组与对照组相比显著降低(P<0.05)。与治疗前相比,两组患者PSQI量表各项评分及其总分显著降低(P<0.05),生活质量各项评分显著升高(P<0.05),且观察组与对照组相比均显著改善(P<0.05)。两组患者不良反应发生率比较差异无统计学意义(P>0.05)。结论枣仁安神颗粒联合阿普唑仑治疗老年失眠合并焦虑抑郁,改善情绪,提高睡眠质量及生活质量,较单用阿普唑仑效果佳,且未增加不良反应。Objective To explore the efficacy and safety of zaoren anshen keli combined with alprazolam in the treatment of elderly patients with insomnia complicated by anxiety and depression.Methods A total of 100 elderly patients with insomnia combined with anxiety and depression who were treated in Hengxi Branch of Medical Community of People's Hospital Affiliated to Ningbo University from July 1,2018 to July 31,2021 were selected and divided into the control group(n=50)and the obser⁃vation group(n=50)according to the random number table method.The control group was given alprazolam,and zaoren ansh⁃en keli combined with alprazdam was given in the observation group.The self-rating anxiety scale(SAS),self-rating depression scale(SDS),pittsburgh sleep quality index(PSQI)scores,quality of life and adverse reactions were compared between the two groups.Results After treatment,the average SAS scores and SDS scores of the two groups were(44.05±2.78)and(52.38±2.62),respectively.The mean SDS scores of the two groups were(44.07±1.59)and(47.26±1.64),respectively.Compared with pre-treatment,the SAS and SDS scores of the two groups significantly decreased after treatment(all P<0.05),and the obser⁃vation group significantly decreased compared with the control group(P<0.05).Compared with pre-treatment,the scores of PSQI scale and total score in the two groups significantly decreased(P<0.05),and the scores of quality of life significantly in⁃creased(P<0.05),and the observation group significantly improved compared with the control group(P<0.05).There was no significant difference in the incidence of adverse reactions between the two groups(P>0.05).Conclusion Zaoren anshen keli combined with alprazolam is more effective than alprazolam in the treatment of elderly patients with insomnia complicated by anxiety and depression,improving mood,improving sleep quality and quality of life,without increasing adverse reactions.

关 键 词：枣仁安神颗粒 阿普唑仑 失眠症 老年 焦虑 抑郁 

分 类 号：R932[医药卫生—生药学] R971[医药卫生—药学]