不同疗程青霉素对先天性梅毒TRUST转阴率的影响:一项基于55例患儿的回顾性研究  

Effect of different treatment regimens of penicillin on the TRUST negative rate of congenital syphilis:a retrospective study of 55 children

作　　者：杨洪玲 伦文辉 王彩英 张慧敏 庞琳 YANG Hong-ling;LUN Wen-hui;WANG Cai-ying;ZHANG Hui-min;PANG Lin(Department of Pediatrics,Beijing Ditan Hospital,Capital Medical University,Beijing 100015,China)

机构地区：[1]首都医科大学附属北京地坛医院儿科,北京100015

出　　处：《临床药物治疗杂志》2022年第11期36-39,共4页Clinical Medication Journal

基　　金：首都医科大学附属北京地坛医院院内科研基金“启航计划”项目(DTQH201608);首都临床特色应用研究课题(Z181100001718140)。

摘　　要：目的研究不同疗程青霉素对先天性梅毒患儿甲苯胺红不加热血清试验(TRUST)转阴率的影响。方法回顾性纳入首都医科大学附属北京地坛医院儿科2015年1月至2019年6月期间接受青霉素治疗的先天性梅毒患儿。根据接受青霉素疗程不同分为观察组与对照组,观察组患者接受青霉素2个疗程治疗;对照组患者接受青霉素1个疗程治疗,于治疗后3、6、9、12个月分别进行随访观察梅毒TRUST转阴情况,分析不同方案对TRUST转阴率的影响。结果共纳入55例接受青霉素治疗的先天性梅毒患儿,其中观察组30例,对照组25例。治疗后随访至3、6、9个月时,观察组梅毒TRUST转阴率高于对照组,但差异无统计学意义(P>0.05)。而12个月时,观察组梅毒TRUST阴转率高于对照组(50%比20%),差异有统计学意义(P<0.05)。两组患者在治疗后及随访12个月内均无发生过敏性休克、严重赫氏反应等不良反应。结论先天性梅毒患儿在治疗时采用青霉素2个疗程的方案,在TRUST转阴率方面较青霉素1个疗程的方案临床效果明显。Objective To study the difference of the negative rate of toluidine red unheated serum test(TRUST)in chil⁃dren with congenital syphilis by different courses of penicillin.Methods The children with congenital syphilis who were treat⁃ed with penicillin from January 2015 to June 2019 in the Department of Pediatrics of Beijing Ditan Hospital Affiliated to Capital Medical University were retrospectively included.According to the different courses of treatment,the patients in the observa⁃tion group were divided into the observation group and the control group.Patients in the observation group received two cours⁃es of penicillin treatment,while the control group received one course.After 3,6,9 and 12 months of treatment,they were fol⁃lowed up to observe the TRUST negative conversion of syphilis,and analyzed the impact of different schemes on the TRUST negative conversion rate.Results A total of 55 children with congenital syphilis treated with penicillin were enrolled,includ⁃ing 30 in the observation group and 25 in the control group.Follow-up to 3,6 and 9 months after treatment,the negative con⁃version rate of TRUST in the observation group was higher than that in the control group,and there was no significant differ⁃ence in the two groups(P>0.05).At 12 months of follow-up,the negative conversion rate of TRUST in the observation group was higher than that in the control group(50%vs 20%),and the difference between the two groups was statistically significant(P<0.05).There were no adverse reactions such as anaphylactic shock and severe hirschell reaction in the two groups after treatment and within 12 months of follow-up.Conclusion The clinical effect of two courses of penicillin in the treatment of children with congenital syphilis is more effective than that of one in term of the negative rate of TURST.

关 键 词：先天性梅毒 青霉素治疗方案 甲苯胺红不加热血清试验 

分 类 号：R978.11[医药卫生—药品] R969.3[医药卫生—药学]