Therapeutic potential of traditional Chinese medicine for the treatment of NAFLD:A promising drug Potentilla discolor Bunge  

作　　者：Longshan Ji Qian Li Yong He Xin Zhang Zhenhua Zhou Yating Gao Miao Fang Zhuo Yu Robim M.Rodrigues Yueqiu Gao Man Li 

机构地区：[1]Laboratory of Cellular Immunity,Institute of Clinical Immunology,Shanghai Key Laboratory of Traditional Chinese Medicine,Shuguang Hospital Affiliated to Shanghai University of Traditional Chinese Medicine,Key Laboratory of Liver and Kidney Diseases(Shanghai University of Traditional Chinese Medicine),Ministry of Education,Shanghai 201203,China [2]Shanghai Institute of Materia Medica,Chinese Academy of Sciences,Shanghai 201203,China [3]Department of Hepatopathy,Shuguang Hospital Affiliated to Shanghai University of Traditional Chinese Medicine,Shanghai 201203,China [4]Department of in Vitro Toxicology and Dermato-Cosmetology,Faculty of Medicine and Pharmacy,Vrije Universiteit Brussel,Brussels 1000,Belgium

出　　处：《Acta Pharmaceutica Sinica B》2022年第9期3529-3547,共19页药学学报（英文版）

基　　金：partly supported by National Natural Science Foundation of China (Nos. 82074155, 81874436, 81973773, China);“Shuguang Program” supported by Shanghai Education Development Foundation and Shanghai Municipal Education Commission (No. 18SG39, China);Program of Shanghai Academic/Technology Research Leader (No. 20XD1423500, China);Clinical Research Plan of SHDC (No. SHDC2020CR3089B, China);Shanghai Key Clinical Specialty Construction Project (No.shslczdzk01201, China);Shanghai Frontier Research Base of Disease and Syndrome Biology of inflammatory cancer transformation (No. 2021KJ03-12, China);Shanghai Sailing Program (No. 20YF1450200, China);Shanghai Collaborative Innovation Center of Industrial Transformation of Hospital TCM Preparation (China)

摘　　要：Nonalcoholic fatty liver disease(NAFLD)is characterized by excessive accumulation of hepatic lipids and metabolic stress-induced liver injury.There are currently no approved effective pharmacological treatments for NAFLD.Traditional Chinese medicine(TCM)has been used for centuries to treat patients with chronic liver diseases without clear disease types and mechanisms.More recently,TCM has been shown to have unique advantages in the treatment of NAFLD.We performed a systematic review of the medical literature published over the last two decades and found that many TCM formulas have been reported to be beneficial for the treatment of metabolic dysfunctions,including Potentilla discolor Bunge(PDB).PDB has a variety of active compounds,including flavonoids,terpenoids,organic acids,steroids and tannins.Many compounds have been shown to exhibit a series of beneficial effects for the treatment of NAFLD,including anti-oxidative and anti-inflammatory functions,improvement of lipid metabolism and reversal of insulin resistance.In this review,we summarize potential therapeutic effects of TCM formulas for the treatment of NAFLD,focusing on the medicinal properties of natural active compounds from PDB and their underlying mechanisms.We point out that PDB can be classified as a novel candidate for the treatment and prevention of NAFLD.

关 键 词：Nonalcoholic fatty liver disease(NAFLD) Traditional Chinese medicine ACUPUNCTURE Potentilla discolor Bunge(PDB) Natural active compounds Anti-oxidative ANTI-INFLAMMATORY Lipid metabolism Insulin resistance Endoplasmic reticulum stress Intestinal microflora 

分 类 号：R285[医药卫生—中药学]