水源水中8种治疗新冠的抗病毒药物的同步检测  

Simultaneous Detection of Eight Antiviral Drugs for Treatment of COVID-19 in Source Water

作　　者：侯云鹤 董紫君[2,3] 宋洪星 李微 闫韫[4] 王路 HOU Yun-he;DONG Zi-jun;SONG Hong-xing;LI Wei;YAN Yun;WANG Lu(School of Municipal and Environmental Engineering,Shenyang Jianzhu University,Shenyang110168,China;School of Materials&Environmental Engineering,Shenzhen Polytechnic,Shenzhen 518055,China;College of Civil and Transportation Engineering,Shenzhen University,Shenzhen 518055,China;Shenzhen Hydrology and Water Quality Center,Shenzhen 518055,China)

机构地区：[1]沈阳建筑大学市政与环境工程学院,辽宁沈阳110168 [2]深圳职业技术学院材料与环境工程学院,广东深圳518055 [3]深圳大学土木与交通工程学院,广东深圳518055 [4]深圳市水文水质中心,广东深圳518055

出　　处：《中国给水排水》2022年第22期130-134,共5页China Water & Wastewater

基　　金：深圳市科技创新委可持续发展专项(专2021N029);国家自然科学基金资助项目(42277373);广东省攀登计划(pdjh2022b0977)。

摘　　要：随着新冠疫情的持续暴发,大量治疗药物不可避免地从不同途径进入水体,在对其进行治理和生态评价时面临准确、快速检测的问题,需要建立同步分析水中多种治疗新冠的抗病毒药物的方法。通过对液相色谱-串联质谱(LC-MS/MS)的测定条件进行优化,构建了一种同步检测水源水中利巴韦林、奥司他伟、奈韦拉平、拉米夫定、阿巴卡韦、司他夫定、阿昔洛韦、喷昔洛韦等8种抗病毒药物的方法。结果表明,该方法的8种抗病毒药物的子离子响应值相对较高,有利于目标化合物的检测;8种抗病毒药物的标准曲线的线性相关系数(r)≥0.9950,检出限(MDL)和测定下限分别为0.004~0.081、0.013~0.267μg/L,实际水样的加标回收率与RSD分别为81.61%~113.03%、0.84%~8.12%。The continuous outbreak of COVID-19 results in a large number of therapeutic drugs inevitably entering water bodies through different pathways,and there are problems of accurate and rapid detection in the treatment and ecological evaluation of these drugs.Therefore,it is necessary to establish a method for simultaneous detection of multiple antiviral drugs for treatment of COVID-19 in water.A method for the simultaneous detection of 8 antiviral drugs(ribavirin,oseltamivir,nevirapine,lamivudine,abacavir,stavudine,acyclovir and penciclovir)in source water was developed by optimizing the determining parameters of liquid chromatography-tandem mass spectrometry(LC-MS/MS).The daughter ion response values of 8 antiviral drugs in this method were relatively high,which was beneficial to the detection of target compounds.The correlation coefficient(r)of the standard curve of 8 antiviral drugs was not less than 0.9950,the method detection limit(MDL)and the lower limit of determination were in the range of 0.004-0.081μg/L and 0.013-0.267μg/L,respectively,and the spike recoveries and RSDs of actual water samples were 81.61%-113.03%and 0.84%-8.12%,respectively.

关 键 词：抗病毒药物 检测方法 水源水 LC-MS/MS 

分 类 号：TU991[建筑科学—市政工程]