血清suPAR、IL-6水平与重症肺炎患者预后的相关性何云霄天台县中医院,浙江台州317200  

Correlation between serum suPAR,IL-6 levels and prognosis of patients with severe pneumonia

作　　者：何云霄[1] HE Yun-xiao(Tiantai County Hospital of Traditional Chinese Medicine,Taizhou,Zhejiang 317200,China)

机构地区：[1]天台县中医院,浙江台州317200

出　　处：《中国卫生检验杂志》2022年第22期2768-2771,2776,共5页Chinese Journal of Health Laboratory Technology

摘　　要：目的 分析血清可溶性尿激酶型纤溶酶原激活物受体(suPAR)、白细胞介素-6(IL-6)表达与重症肺炎(SP)患者预后的关系。方法 回顾性分析,收集医院2018年6月-2021年6月收治117例SP患者资料,全部SP患者均接受血清suPAR、IL-6检测及随访,且相关实验室检测结果、病历资料、随访资料等完整;将患者28 d病死作为预后观察指标并分组,统计患者相关基线资料与实验检测结果,分析血清suPAR、IL-6表达与SP患者预后的关系。结果 随访28 d内,117例SP患者中29例病死,病死率为24.79%;病死SP患者入院时急性生理与慢性健康Ⅱ评分(APACHEⅡ评分)、CRP水平、suPAR水平、IL-6水平均高于存活患者,差异有统计学意义(P<0.05);组间其他基线资料比较差异无统计学意义(P>0.05);经Cox回归分析结果显示,C-反应蛋白(CRP)、suPAR、IL-6过表达均可能是SP患者病死的危险因子(HR分别为1.379、1.354、1.037,P均<0.05);绘制ROC曲线发现,血清suPAR、IL-6单一及联合预测SP患者病死风险的AUC>0.80,均有一定预测价值,且当二者cut-off值分别取7.535 ng/ml、155.665 pg/ml时,可获得最佳预测价值。结论 血清suPAR、IL-6表达与SP患者预后有关,二者过表达可能是SP患者病死的危险因子,临床应重视患者入院时血清suPAR、IL-6表达,可能对预测患者病死风险有一定价值。Objective This study aims to analyze the relationship between the expression of serum soluble urokinase plasminogen activator receptor(suPAR)and interleukin-6(IL-6)and the prognosis of patients with severe pneumonia(SP).Methods A retrospectively analysis was performed and the data of 117 patients with SP treated in the hospital from June 2018 to June 2021 were collected.All SP patients received the detection of serum suPAR and IL-6 and follow-up.The related laboratory test results,medical records and follow-up data were complete;the 28-day fatality was used as a prognostic index,the relevant baseline data and experimental test results of patients were counted,and the relationship between the expression of serum suPAR and IL-6 and the prognosis of SP patients was analyzed.Results Within 28 days of follow-up,of 117 SP patients,29 died from illness,with a fatality rate of 24.79%;the acute physiology and chronic healthⅡscore(APACHEⅡscore),CRP level,suPAR level and IL-6 level of died patients with SP were higher than those of survival patients,with the differences statistically significant(P<0.05);compared other baseline data between groups,there was no statistical significance on the difference(P>0.05);Cox regression analysis showed that the over-expression of C-reactive protein(CRP),suPAR and IL-6 all might be the risk factors of death from illness in SP patients(HR=1.379,HR=1.354,HR=1.037,P<0.05);ROC curve showed that AUC of serum suPAR and IL-6 alone and in combination in predicting fatality risk of SP patients were both>0.80,and when the cut-off values were 7.535 ng/ml and 155.665 pg/ml,the best predictive value could be obtained.Conclusion The expression of serum suPAR and IL-6 is related to the prognosis of SP patients,and the over-expression of the two genes may be a risk factor of death from illness of SP patients.Attention should be paid to the expression of serum suPAR and IL-6 of patients at admission,which may have certain value in predicting the risk of death from illness of patients.

关 键 词：重症肺炎 预后 可溶性尿激酶型纤溶酶原激活物受体 白细胞介素-6 相关性 

分 类 号：R563.1[医药卫生—呼吸系统]