7108例深静脉导管病原学检测结果及耐药性分析  

Etiological detection and drug resistance analysis of 7108 cases of deep venous catheters

作　　者：邱敏 徐柯[2] QIU Min;XU Ke(Center for Clinical Pharmacy,Zhejiang Provincial People’s Hospital,Hangzhou,Zhejiang 310024,China;不详)

机构地区：[1]浙江省人民医院临床药学中心,浙江杭州310024 [2]浙江省人民医院检验医学中心

出　　处：《中国卫生检验杂志》2022年第21期2590-2593,共4页Chinese Journal of Health Laboratory Technology

基　　金：浙江省医药卫生科技计划(2019310930)。

摘　　要：目的了解深静脉导管标本病原学结果及耐药性的特点,为临床诊治提供实验室依据。方法回顾性分析2014年—2021年本院临床科室送检至微生物室的5646份DVC标本的病原学检测结果及耐药性。结果2014年—2021年的5646份深静脉导管标本中,送检标本数量呈上升趋势;DVC病原菌以革兰阳性球菌为主;培养出革兰阳性球菌数量前3位的分别为表皮葡萄球菌(15.23%)、金黄色葡萄球菌(8.40%)、人型葡萄球菌人型亚种(4.37%);61岁~70岁年龄段的患者标本送检量及杆菌、球菌为同类型中最高,而>80岁年龄段的患者真菌的阳性数和标本污染数最高;革兰阳性球菌耐药率前5位的抗菌药物为青霉素G、D实验、苯唑西林、红霉素、氨苄西林。结论深静脉导管中病原菌以革兰阳性球菌为主,临床上应加强60岁以上人群的深静脉导管的培养送检,监控其病原学结果分布和耐药性,合理选用抗菌药物治疗。Objective This study aims to investigate the etiological results and drug resistance characteristics of deep venous catheter specimens,so as to provide laboratory basis for clinical diagnosis and treatment.Methods The etiological test results and drug resistance of 5646 DVC specimens sent to the microbiology laboratory by the clinical department of our hospital from2014 to 2020 were retrospectively analyzed.Results Among the 5646 deep venous catheter specimens from 2014 to 2021,the number of specimens submitted for inspection showed an upward trend;the pathogenic bacteria of DVC was mainly Gram-positive cocci;the top three detection rate of Gram-positive cocci in culture were observed in Staphylococcus epidermidis(15.23%),Staphylococcus aureus(8.40%),Staphylococcus hominis subspecies(4.37%).Patients aged 61-70 years had the highest numbers of Bacilli and Cocci strains in the submitted specimens,while patients aged>80 years had the highest positive number of Fungi strains and the most contaminated specimens.The top five antibiotics in the resistance rate of Gram-positive cocci were penicillin G and D,oxacillin,erythromycin and ampicillin.Conclusion The pathogenic bacteria in deep venous catheters are mainly Gram-positive cocci.Clinically,the culture and inspection of deep venous catheters for people over 60 years old should be strengthened,the etiological distribution and drug resistance should be monitored,and antibiotics should be rationally selected for treatment.

关 键 词：深静脉导管 病原 耐药性 培养 

分 类 号：R446.5[医药卫生—诊断学]