软坚清脉颗粒对急性冠脉综合征患者血清血管内皮生长因子、生长分化因子-15及颈动脉斑块易损性的影响  

Effects of Ruanjian Qingmai granules on serum vascular endothelial growth factor,growth differentiation factor-15 and vulnerability of carotid artery plaque in patients with acute coronary syndrome

作　　者：常肖 王芳[1] 孙芳 CHANG Xiao;WANG Fang;SUN Fang(Department of Cardiology,West Campus of Qingdao Municipal Hospital Qingdao,Shandong 266011,Qingdao Province,China)

机构地区：[1]青岛市市立医院西院心内科,山东青岛266011

出　　处：《世界临床药物》2022年第10期1326-1331,共6页World Clinical Drug

摘　　要：目的探讨软坚清脉颗粒对急性冠脉综合征(acute coronary syndrome,ACS)患者血清血管内皮生长因子(vascular endothelial growth factor,VEGF)、生长分化因子(growth differentiation factor,GDF)-15及颈动脉斑块易损性的影响。方法选择2019年1月至2021年1月青岛市市立医院心内科住院部收治的ACS患者123例,采用随机数表法分为观察组(n=62)和对照组(n=61)。对照组给予阿托伐他汀,观察组给予阿托伐他汀及软坚清脉颗粒。比较两组临床疗效、血清VEGF、GDF-15及颈动脉斑块易损性、脑钠肽(brain natriuretic peptide,BNP)、左心室射血分数(left ventricular ejection fraction,LVEF)变化、心血管不良事件发生情况及药物安全性。结果观察组总有效率较对照组差异具有统计学意义(90.32%vs 72.13%,P<0.05)。治疗后,两组血清GDF-15、颈动脉斑块易损性水平均随时间推移而下降,且观察组低于对照组(P<0.05);血清VEGF水平均随时间推移而升高,且观察组高于对照组(P<0.05)。治疗后,两组血清BNP水平均随时间推移而下降,且观察组低于对照组(P<0.05);LVEF水平随时间推移而升高,且观察组高于对照组(P<0.05)。观察组心血管不良事件发生率均低于对照组,差异具有统计学意义(P<0.05)。结论对ACS患者应用奚氏软坚清脉颗粒效果显著,可能与其可有效改善血清VEGF、GDF-15及颈动脉斑块易损性水平有关。Objective To investigate the effects of Ruanjian Qingmai granules on serum vascular endothelial growth factor(VEGF).Growth differentiation factor(GDF)-15 and carotid plaque vulnerability in patients with acute coronary syndrome(ACS).Methods A total of 123 ACS patients admitted to the department of cardiology,Qingdao municipal hospital from January 2019 to January 2021 were selected and randomly divided into observation group(n=62)and control group(n=62)by random number table method.The control group was given atorvastatin,while the observation group was given atorvastatin and Ruanjian Qingmai granules.The clinical efficacy,serum VEGF,GDF-15,carotid plaque vulnerability,brain natriuretic peptide(BNP)and left ventricular ejection fraction(LVEF),cardiovascular adverse events and drug safety were compared between the two groups.Results The total effective rate of the observation group was higher than that of the control group(90.32%vs 72.13%,P<0.05).After treatment,the levels of serum GDF-15 and carotid plaque vulnerability in the two groups decreased with time,and the observation group were lower than those in the control group(P<0.05).Serum VEGF levels were increased with time,and the observation group was higher than that in the control group(P<0.05).After treatment,the serum BNP levels of the two groups decreased with time,and the observation group was lower than that of the control group(P<0.05).LVEF level increased with time,and the observation group was higher than that in the control group(P<0.05).The incidence of adverse cardiovascular events in the observation group was lower than that in the control group,and the difference was statistically significant(P<0.05).Conclusion The effect of Ruanjian Qingmai granules on ACS patients is significant,which may be related to the effective improvement of serum VEGF,GDF-15 and carotid plaque vulnerability.

关 键 词：奚氏软坚清脉颗粒 急性冠脉综合征 血管内皮生长因子 生长分化因子-15 颈动脉斑块易损性 

分 类 号：R541.4[医药卫生—心血管疾病] R256.2[医药卫生—内科学]