基于炎症学说探讨巨噬细胞极化与骨质疏松症相关性  

Discussion on Relationship between Macrophage Polarization and Osteoporosis Based on Inflammation Theory

作　　者：马晨光 杨青峰 于继凯 周玉英 蒋宜伟 MA Chenguang;YANG Qingfeng;YU Jikai;ZHOU Yuying;JIANG Yiwei(Clinical College of Chinese Medicine,Gansu University of Chinese medicine,Lanzhou 730101,Gansu,China;Affiliated Hospital of Gansu University of Chinese Medicine,Lanzhou 730020,Gansu,China)

机构地区：[1]甘肃中医药大学中医临床学院,甘肃兰州730101 [2]甘肃中医药大学附属医院,甘肃兰州730020

出　　处：《中华中医药学刊》2022年第11期114-117,I0019,共5页Chinese Archives of Traditional Chinese Medicine

基　　金：国家自然科学基金地区基金(82160916);甘肃省自然科学基金(1010RJZA160);甘肃省中医药管理局基金(GZK-2017-17);兰州市科技计划(2021-1-95)。

摘　　要：骨质疏松症(osteoporosis, OP)是一种由于骨量丢失、骨微观结构破坏而易骨折的进行性骨病,其发病机制仍未被完全阐释清楚。有关研究表明,慢性炎症是导致骨质疏松症发展的重要原因之一,尤其是巨噬细胞极化诱导的慢性炎症,巨噬细胞极化过程中大量炎症因子通过调控相关衍生物合成,打破成骨细胞与破骨细胞之间的平衡性,影响骨质疏松症的发生发展。基于炎症学说对巨噬细胞极化与骨质疏松症相关性的具体机制作用进行简要综述,旨在为骨质疏松症相关分子机制研究提供新思路。Objective Osteoporosis is a progressive bone disease that is prone to fracture due to loss of bone mass and destruction of bone microstructure,and its pathogenesis has not been fully explained.Related studies have shown that chronic inflammation is one of the important cause leading to the development of osteoporosis,especially chronic inflammation induced by macrophage polarization.In the process of macrophage polarization,a large number of inflammatory factors break the balance between osteoblasts and osteoclasts by regulating the synthesis of related derivatives and affect the occurrence and development of osteoporosis.Based on inflammation theory,this paper briefly reviewed the specific mechanism of macrophage polarization and osteoporosis,aiming to provide new ideas for the study of osteoporosis related molecular mechanism.

关 键 词：炎症学说 巨噬细胞极化 骨质疏松症 综述 

分 类 号：R269.81[医药卫生—中西医结合]