基于维生素D探讨中医补肾药治疗多发性硬化症的潜在靶点  

Exploration on Mechanism of Kindey-Tonifying Chinese Medicine on Multiple Sclerosis Based on Vitamin D

作　　者：晏一平 陈波洋 于海洋 张旭飞 陈云志 YAN Yiping;CHEN Boyang;YU Haiyang;ZHANG Xufei;CHEN Yunzhi(Guizhou University of Traditional Chinese Medicine,Guiyang 550025,Guizhou,China)

机构地区：[1]贵州中医药大学,贵州贵阳550025

出　　处：《中华中医药学刊》2022年第11期185-189,共5页Chinese Archives of Traditional Chinese Medicine

基　　金：国家自然科学基金(81874376);贵州省重点学科建设项目。

摘　　要：多发性硬化症(multiple sclerosis)是一种以肢体无力、感觉异常、运动功能障碍等为主要临床表现的中枢神经系统疾病。维生素D(vitamin D)是人体重要的脂溶性类固醇激素之一,其不仅能改善骨骼类疾病,还对多发性硬化症的发展存在一定调控作用。中医认为多发性硬化症属于“痿病”“痹病”的范畴,因其病机为本虚标实,故常应用扶正固本补肾疗法防治多发性硬化症。扶正固本补肾药与维生素D的作用靶点存在密切联系。故推测,中医扶正固本补肾疗法通过调节维生素D防治多发性硬化症。维生素D可能是扶正固本补肾药防治多发性硬化症的潜在靶点。Multiple sclerosis is a central nervous system disease with limb weakness,paresthesia and motor dysfunction as the main clinical manifestations.Vitamin D is one of the important fat-soluble steroid hormones in the human body.It not only can improve bone diseases,but also has a certain regulatory effect on the development of multiple sclerosis.Traditional Chinese medicine believes that multiple sclerosis belongs to the category of"flaccid disease"and"Bi syndrome".Because its pathogenesis is deficiency in origin and excess in superficislity,the therapy of strengthening the body and tonifying kidney is often used to prevent and treat multiple sclerosis.There is a close relationship between the Chinese medicine for strengthening the body and tonifying kidney and the target of vitamin D.Therefore,it is speculated that the traditional Chinese medicine therapy of strengthening the body and tonifying kidney prevents and treats multiple sclerosis by regulating vitamin D.Vitamin D may be a potential target for strengthening the body and tonifying kidney to prevent and treat multiple sclerosis.

关 键 词：维生素D 补肾药 多发性硬化症 

分 类 号：R277.745.51[医药卫生—中医学]