Lateral Hypothalamus Calcium/Calmodulin-Dependent Protein Kinase IIα Neurons Encode Novelty-Seeking Signals to Promote Predatory Eating  

作　　者：Na Tan Jiaying Shi Lingyu Xu Yanrong Zheng Xia Wang Nanxi Lai Zhuowen Fang Jialu Chen Yi Wang Zhong Chen 

机构地区：[1]Institute of Pharmacology and Toxicology,College of Pharmaceutical Sciences,Zhejiang University,Hangzhou,China [2]Key Laboratory of Neuropharmacology and Translational Medicine of Zhejiang Province,School of Pharmaceutical Sciences,Zhejiang Chinese Medical University,Hangzhou,China

出　　处：《Research》2022年第4期657-675,共19页研究（英文）

基　　金：This work was supported by fundings as follows:National Key R&D Program of China(2021ZD0202803);National NaturalScienceFoundationof China(U21A20418,82022071,and 81821091);Fundamental Research Funds forthe Central Universities(2021QNA7022).

摘　　要：Predatory hunting is an innate appetite-driven and evolutionarily conserved behavior essential for animal survival, integrating sequential behaviors including searching, pursuit, attack, retrieval, and ultimately consumption. Nevertheless, neural circuits underlying hunting behavior with different features remain largely unexplored. Here, we deciphered a novel function of lateral hypothalamus (LH) calcium/calmodulin-dependent protein kinase II α (CaMKIIα^(+)) neurons in hunting behavior and uncovered upstream/downstream circuit basis. LH CaMKIIα^(+) neurons bidirectionally modulate novelty-seeking behavior, predatory attack, and eating in hunting behavior. LH CaMKIIα^(+) neurons integrate hunting-related novelty-seeking information from the medial preoptic area (MPOA) and project to the ventral periaqueductal gray (vPAG) to promote predatory eating. Our results demonstrate that LH CaMKIIα^(+) neurons are the key hub that integrate MPOA-conveyed novelty-seeking signals and encode predatory eating in hunting behavior, which enriched the neuronal substrate of hunting behavior.

关 键 词：SEEKING INTEGRATE integrating 

分 类 号：R33[医药卫生—人体生理学]