艾滋病毒/丙肝病毒共感染在不同时期的流行及治疗效果观察  

Analysis of epidemic and infection characteristics of human immunodeficiency virus/ hepatitis C virus co-infection in different periods

作　　者：马丽琴 盖敬云 李汾香 MA Liqin;GAN Jingyun;LI Fenxiang(Third People's Hospital of Linfen,Linfen 041000,China)

机构地区：[1]临汾市第三人民医院,山西临汾041000

出　　处：《临床医药实践》2023年第1期40-43,共4页Proceeding of Clinical Medicine

摘　　要：目的:分析艾滋病毒/丙肝病毒(HIV/HCV)合并感染在不同时期的流行及感染特征,评价不同抗病毒方案的临床疗效。方法:将2007年临汾市第三人民医院收治的HIV/HCV感染者纳入本次观察,采取横断面研究分析方法,观察2007年与2020年感染者的流行率、HCV复制、感染特征等,比较干扰素与直接抗病毒药物(DAA)的持续病毒应答率。结果:2007年HIV/HCV合并感染率为46.43%,2020年HIV/HCV的感染率下降至4.24%;2020年性传播的比例增加,出现了同性传播。1b亚型为两个时期的主要基因分型,占76.00%。DAA组的12周持续病毒应答率(SVR12)为94.70%,观察至48周仍保持为94.70%;干扰素组的SVR12为71.40%,观察至144周下降至28.60%;DAA组不良反应少,主动退出者明显少于干扰素组,完成治疗疗程者达100%。结论:HIV/HCV感染者应尽早使用DAA进行抗HCV治疗,并加强对男男性行为(MSM)人群的HCV筛查力度。Objective: To analyze the epidemic and infection characteristics of human immunodeficiency virus/hepatitis C virus(HIV/HCV) coinfection in different periods, and to evaluate the clinical efficacy of different antiviral regimens.Methods: HIV/HCV infected persons managed in Linfen third hospital since 2007 were included in this observation.The prevalence, HCV replication and infection characteristics of infected persons in 2007 and 2020 were observed by cross-sectional analysis, and the sustained virus inhibition rates of interferon and direct antiviral drug(DAA) were compared.Results: The infection rate of HIV/HCV was 46.43%,the infection rate of HIV/HCV decreased to 4.24% in 2020,the proportion of sexual transmission was increased in 2020,and there will be same-sex transmission.Subtype 1 b was the main genotype in the two stages, accounting for 76.00%.12 weeks sustained virological response(SVR12) was 94.70% in DAA group and remained 94.70% at 48 weeks, SVR12 was 71.40% in interferon group and decreased to 28.60% at 144 weeks.There were fewer adverse reactions in DAA group, the number of active withdrawal was significantly less than that in interferon group, 100% of patients completed the treatment course.Conclusion: HIV/HCV infected people should use DAA for anti HCV treatment as soon as possible, and strengthen HCV screening in MSM population.

关 键 词：艾滋病毒/丙肝病毒 干扰素 直接抗病毒药物 持续病毒应答率 

分 类 号：R373.51[医药卫生—病原生物学]