舒芬太尼用于洛匹那韦/利托那韦治疗HIV感染患者术后自控静脉镇痛的临床疗效观察  

Clinical effect of sufentanil for postoperative patient controlled intravenous analgesia in patients with HIV infection treated with lopinavir/ritonavir

作　　者：赵娜娜 聂超然 赵丽琴[1] 牛少宁[1] 刘欣娜 程灏 Zhao Nana;Nie Chaoran;Zhao Liqin;Niu Shaoning;Liu Xinna;Cheng Hao(Department of Anesthesiology,Beijing Ditan Hospital,Capital Medical University,Beijing 100015,China)

机构地区：[1]首都医科大学附属北京地坛医院麻醉科,100015 [2]首都医科大学宣武医院麻醉科

出　　处：《北京医学》2022年第9期787-789,794,共4页Beijing Medical Journal

基　　金：北京市医院管理局临床医学发展专项——“扬帆”计划(XMLX202148)。

摘　　要：目的探讨舒芬太尼用于洛匹那韦/利托那韦治疗HIV感染患者术后自控静脉镇痛的临床疗效。方法选取2019年1月至2021年12月首都医科大学附属北京地坛医院行腹腔镜胆囊切除术的患者100例,根据是否合并HIV感染分为HIV感染组(E组)和非HIV感染组(C组),每组50例;合并HIV感染组均接受洛匹那韦/利托那韦治疗。比较两组术后24 h和48 h的患者自控静脉镇痛泵(patient controlled intravenous analgesia,PCIA)总量、PCIA按压次数、静息视觉模拟评分(visual analogue score,VAS)和活动VAS、PCIA不良反应发生率。结果两组PCIA总量、PCIA按压次数、静息VAS及活动VAS、头晕嗜睡发生率比较,差异均无统计学意义(P>0.05);E组术后恶心呕吐发生率及排气延迟发生率均高于C组(28.0%比12.0%,26.0%比10.0%),差异有统计学意义(P<0.05)。结论洛匹那韦/利托那韦可以增强舒芬太尼不良反应,但并不影响镇痛效果。Objective To investigate the clinical efficacy of sufentanil for postoperative patient controlled intravenous analgesia(PCIA)in patients with HIV infection treated with lopinavir/ritonavir.Methods A total of 100 patients who underwent laparoscopic cholecystectomy in Beijing Ditan Hospital,Capital Medical University from January 2019 to December 2021 were selected and divided into HIV infection group(group E)and non-HIV infection group(group C)according to whether they were complicated with HIV infection,with 50 patients in each group.All patients with HIV infection received lopinavir/ritonavir treatment.The total amount of PCIA,the number of PCIA compressions,resting visual analogue score(VAS)and active VAS,and the incidence of PCIA adverse reactions were compared between the two groups at24 h and 48 h after operation.Results There were no significant differences in the total amount of PCIA,the number of PCIA compressions,resting VAS and active VAS,and the incidence of dizziness and sleepiness between the two groups(P>0.05).The incidence of postoperative nausea and vomiting and the incidence of delayed exhaust in group E were higher than those in group C(28.0%vs.12.0%,26.0%vs.10.0%),and the difference was statistically significant(P<0.05).Conclusions Lopinavir/ritonavir can enhance the adverse reaction of sufentanil,but does not affect the analgesic effect.

关 键 词：洛匹那韦/利托那韦 舒芬太尼 HIV感染 术后镇痛 

分 类 号：R614[医药卫生—麻醉学]