重症肺炎患者早期给予气管插管机械通气治疗的益处及对缩短病程、降低死亡率的影响  

Benefits of early endotracheal intubation and mechanical ventilation in patients with severe pneumonia and its effect on shortening the course of disease and reducing mortality

作　　者：郭在裕 Guo Zaiyu(Department of critical medicine,people's Hospital of Ji'an County,Ji'an,Jiangxi 343100,China)

机构地区：[1]江西省吉安县人民医院,江西吉安343100

出　　处：《首都食品与医药》2022年第22期59-62,共4页Capital Food Medicine

摘　　要：目的 探讨气管插管机械通气应用于重症肺炎患者早期治疗中的益处及对缩短病程、降低死亡率的影响.方法 选取2019年8月-2020年2月江西省吉安县人民医院收治的重症肺炎患者共计60例,根据随机摸球法分成观察组(n=30)与对照组(n=30),对照组采用常规治疗,观察组采用气管插管机械通气治疗,对两组患者的临床指标、血气指标、炎症反应及死亡率进行比较.结果 观察组的咳嗽缓解时间、住院时间较对照组明显更短(P<0.05);治疗后两组动脉血氧分压(PaO_(2))、血氧饱和度(SaO_(2))明显提高(P<0.05),动脉血二氧化碳分压(PaCO_(2))明显降低(P<0.05),观察组PaO_(2)、SaO_(2)较对照组明显更高(P<0.05),观察组PaCO_(2)较对照组明显更低(P<0.05);治疗后两组C反应蛋白(CRP)、血清降钙素原(PCT)、白细胞计数明显降低(P<0.05),观察组较对照组明显更低(P<0.05);观察组的死亡率(3.33%)较对照组(26.67%)明显更低(P<0.05).结论 重症肺炎患者早期给予气管插管机械通气治疗可缩短咳嗽缓解时间及住院时间,改善血气指标,减少炎症反应,降低死亡率.Object ive To explore the benefits of endotracheal intubation mechanical ventilation in the early treatment of severe pneumonia and its impact on shortening the course of disease and reducing mortality.Methods A total of 60 patients with severe pneumonia treated in our hospital from August 2019 to February 2020 were randomly divided into observation group(n=30)and control group(n=30).The control group was treated with routine treatment,and the observation group was treated with endotracheal intubation and mechanical ventilation.The clinical indicators,blood gas indicators,inflammatory response and mortality of the two groups were compared.Results The cough relief time and hospitalization time in the observation group were significantly shorter than those in the control group(P<0.05);after treatment,arterial partial pressure of oxygen(Pa02)and saturation of oxygen(Sa02)were significantly increased(P<0.05),arterial partial pressure of carbon dioxide(PaCO_(2))was significantly decreased(P<0.05),Pa02 and Sa02 in the observation group were significantly higher than those in the control group(P<0.05),and PaCO,in the observation group was significantly lower than those in the control group(P<0.05);after treatment,C-reactive protein(CRP),serum procalcitonin(PCT)and leukocyte count decreased significantly in the two groups(P<0.05),and the observation group was significantly lower than the control group(P<0.05);the mortality of the observation group(3.33%)was significantly lower than that of the control group(26.67%)(P<0.05).Conc lus ion Early treatment with endotracheal intubation and mechanical ventilation in patients with severe pneumonia can shorten cough relief time and hospitalization time,improve blood gas indicators,reduce inflammatory reaction and reduce mortality.

关 键 词：重症肺炎 气管插管机械通气 死亡率 血气指标 炎症反应 

分 类 号：R563.1[医药卫生—呼吸系统]