孕期女性TORCH感染及相关因素调查  

Serological investigation of TORCH infection in pregnant women and analysis of related factors

作　　者：马威[1] 魏波[1] 于辛酉[1] MA Wei;WEI Bo;YU Xin-You(General Hospital of Ningxia Medical University,Antenatal Diagnostic Center,Yinchuan 750004,China)

机构地区：[1]宁夏医科大学总医院产前诊断中心,宁夏银川750004

出　　处：《中国病原生物学杂志》2022年第11期1315-1318,共4页Journal of Pathogen Biology

基　　金：宁夏回族自治区重点研发计划项目(No.2021BEG03043)。

摘　　要：目的分析本地区孕期女性TORCH感染血清学调查结果及感染相关因素,为促进本地区优生优育工作提供参考依据。方法采用磁微粒化学发光免疫分析法测定巨细胞病毒、风疹病毒、弓形虫IgM抗体,采用酶联免疫吸附测定法检测单纯疱疹病毒IgM抗体。回顾性分析1362例孕期女性的病历资料,跟踪随访观察其妊娠结局。结果1362例孕期女性中,7.05%TORCH-IgM抗体检查结果阳性,其中3.82%为巨细胞病毒阳性,1.40%为单纯疱疹病毒(1/2)型阳性,1.03%为风疹病毒阳性,0.81%为弓形虫阳性。初次妊娠女性中,感染率为6.67%,≥2次妊娠女性中,感染率为7.54%,两组孕期女性TORCH感染率差异无统计学意义。TORCH感染率与受教育文化程度、月收入情况、动物接触史、异常妊娠史、阴道炎有关,与患者年龄、居住环境无关。对影响孕期女性TORCH感染率的危险因素采用二元Logistic回归分析发现,受教育文化程度为大专以下、月收入情况≤4000元、有动物接触史、有异常妊娠史,是孕期女性TORCH感染独立危险因素。96例TORCH-IgM检查结果阳性者作为感染组,34.38%出现妊娠不良结局;未感染组中,6.00%出现妊娠不良结局。不良妊娠结局主要为宫内感染,共37例。感染组出现不良妊娠结局的发生率,宫内感染、流产、早产、胎儿发育迟缓、畸胎、新生儿窒息的发生率,均高于未感染组,对比差异具有统计学意义。本次研究中,8.00%发生不良妊娠结局。按照妊娠结局分成两组,对比两组的TORCH-IgM阳性率,不良妊娠组高于正常组,差异具有统计学意义。结论本地区孕期女性中,TORCH-IgM抗体检查结果阳性者主要为巨细胞病毒阳性,TORCH感染率与受教育文化程度、月收入情况、动物接触史、异常妊娠史、阴道炎有关。TORCH感染者出现不良妊娠结局的发生率,高于未感染女性。女性在孕前及孕早期接受TORCH血清筛查具有重要意义。Objective To analyze the serological investigation results and infection related factors of TORCH infection in pregnant women in this region,so as to provide reference basis for promoting the work of birth and child rearing in this region.Methods The IgM antibodies of cytomegalovirus,rubella virus and Toxoplasma gondii were detected by magnetic particle chemiluminescence immunoassay,and the IgM antibodies of herpes simplex virus were detected by ELISA.The medical records of 1362 pregnant women who participated in this study were retrospectively analyzed,and their pregnancy outcomes were followed up.Results Among 1362 pregnant women in this study,7.05%of TORCH IgM antibody test results were positive,of which 3.82%were cytomegalovirus positive,1.40%were herpes simplex virus(1/2)positive,1.03%were rubella virus positive,and 0.81%were Toxoplasma gondii positive.Among the first pregnant women,the infection rate was 6.67%,and among the women with≥2 pregnancies,the infection rate was 7.54%.There was no significant difference in TORCH infection rate between the two groups.The analysis of the case data of pregnant women participating in the study found that the torch infection rate was related to education and education,monthly income,animal contact history,abnormal pregnancy history,vaginitis,and the torch infection rate was not related to the patient’s age and living environment.The risk factors affecting TORCH infection rate in pregnant women were further analyzed by binary logistic regression.It was found that the education level below junior college,monthly income≤4000 yuan,animal contact history and abnormal pregnancy history were independent risk factors for TORCH infection in pregnant women.96 cases with torch IgM positive results were regarded as the infection group,and 34.38%of them had adverse pregnancy outcomes;In the uninfected group,6.00%had adverse pregnancy outcomes.The adverse pregnancy outcome was mainly intrauterine infection,and there was 37 cases.The incidence of adverse pregnancy outcomes,intra

关 键 词：巨细胞病毒 风疹病毒 单纯疱疹病毒 弓形虫 相关因素 不良妊娠结局 

分 类 号：R37[医药卫生—病原生物学]