尼可地尔治疗老年心力衰竭患者心脏舒张功能和衰弱的影响  

Effect of Nicorandil in the treatment of elderly patients with heart failure and the influence on cardiac diastolic function and prognosis

作　　者：田晓晨 李静 韩涛 路平[4] TIAN Xiaochen;LI Jing;HAN Tao;LU Ping(Second Department of Cardiovascular Medicine,the Fourth People's Hospital of Jinan,Jinan Shandong 250000,China)

机构地区：[1]济南市第四人民医院心血管内二科,山东济南250000 [2]济南市机关医院内科,山东济南250000 [3]济南市第四人民医院北村社区卫生服务中心,山东济南250000 [4]济南市第四人民医院急诊与重症医学科,山东济南250000

出　　处：《中国急救复苏与灾害医学杂志》2022年第12期1594-1597,共4页China Journal of Emergency Resuscitation and Disaster Medicine

基　　金：山东省医药卫生科技发展计划项目(编号:202103010573)。

摘　　要：目的探讨尼可地尔治疗老年心力衰竭患者的效果及其对心脏舒张功能和预后的影响。方法选择济南市第四人民医院2020年1月—2022年2月收治的80例老年心力衰竭患者作为研究对象,按照随机信封法将其分为对照组和观察组,每组40例。对照组患者采用单硝硬异山梨酯缓释片治疗,观察组患者在对照组基础上采用尼可地尔治疗。比较两组的临床疗效、衰弱情况、心脏舒张功能及预后情况。结果观察组治疗总有效率高于对照组,差异有统计学意义(P<0.05)。治疗后,两组患者衰弱情况均好于治疗前,且观察组好于对照组,差异有统计学意义(P<0.05)。治疗后,两组患者左室舒张末期内径(LVEDD)、室间隔厚度(IVST)均小于治疗前,左室射血分数(LVEF)、舒张早期心室充盈速度峰值(VE)/舒张晚期心室充盈速度峰值(VA)均高于治疗前,且观察组患者LVEDD、IVST均小于对照组,LVEF、VE/VA均高于对照组,差异有统计学意义(P<0.05)。治疗后,观察组患者不良心血管事件总发生率低于对照组,差异有统计学意义(P<0.05)。结论尼可地尔治疗老年心力衰竭可显著提高患者临床疗效,改善患者心脏舒张功能及衰弱状态。Objective To investigate the effect of Nicorandil in the treatment of elderly patients with heart failure and the influence on cardiac diastolic function and prognosis.Methods A total of 80 elderly patients with heart failure treated in the Fourth People’s Hospital of Jinan from January 2020 to February 2022 were selected and divided into the control group and the observation group according to the random envelope method,with 40 cases in each group.The control group was treated with Isosorbide Mononitrate Sustained-release Tablets,and the observation group was treated with Nicorandil on the basis of the control group.The clinical efficacy,weakness,diastolic function and prognosis of the two groups were compared.Results The total effective rate of the observation group was higher than that of the control group,and the difference was statistically significant(P<0.05).After treatment,the weakness of the two groups was better than that before treatment,and the weakness of the observation group was better than that of the control group,the difference was statistically significant(P<0.05).After treatment,the left ventricular end diastolic diameter(LVEDD)and interventricular septal thickness(IVST)of the two groups were less than those before treatment,the left ventricular ejection fraction(LVEF)and peak ventricular filling velocity in the early diastole(VE)/peak ventricular filling velocity in the late diastole(VA)of the two groups were higher than those before treatment,and the LVEDD and IVST of the observation group were less than those of the control group,the LVEF and VE/VA of the observation group were higher than those of the control group,and the difference was statistically significant(P<0.05).After treatment,the total incidence of adverse cardiovascular events in the observation group was lower than that in the control group,and the difference was statistically significant(P<0.05).Conclusion Nicorandil in the treatment of elderly patients with heart failure can significantly improve the clinical efficacy,dias

关 键 词：衰弱量表评分 尼可地尔 老年心力衰竭 心脏舒张功能 预后 

分 类 号：R541.6[医药卫生—心血管疾病]