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作 者:吕俊 陈侃俊 王华萍 石炜弘 沈若冰[2] 余小萍[2] LYU Jun;CHEN Kanjun;WANG Huaping;SHI Weihong;SHEN Ruobing;YU Xiaoping(Shanghai Pudong New District Geriatric Hospital,Shanghai 201314,China;Shuguang Hospital Affiliated to Shanghai University of Traditional Chinese Medicine,Shanghai 201203,China)
机构地区:[1]上海市浦东新区老年医院,上海201314 [2]上海中医药大学附属曙光医院,上海201203
出 处:《中医药学报》2022年第12期71-77,共7页Acta Chinese Medicine and Pharmacology
基 金:国家自然科学基金项目(81904127);浦东新区卫生和计划生育委员会青年科技项目(pw2018B-14)。
摘 要:目的:观察蝉芩颗粒治疗风痰恋肺型感染后咳嗽患者的临床疗效及其相关机制。方法:选择85例感染后咳嗽患者,随机分为蝉芩颗粒组43例和阿斯美组42例,疗程为14 d。比较两组症状程度、咳嗽缓解时间、HARQ气道反流量表积分、SP和IL-6水平。结果:蝉芩颗粒组在咳嗽、咽痒程度上均低于阿斯美组(P<0.05);蝉芩颗粒组咳嗽缓解时间比阿斯美组短,咳痰症状随着治疗时间逐渐变轻;蝉芩颗粒组患者气短、恶风、胸闷、口干和大便干结症状的发生率下降(P<0.01);蝉芩颗粒组HARQ积分随着治疗时间延长有逐渐降低的趋势;两组治疗后SP、IL-6水平较治疗前均有所降低(P<0.01)。结论:蝉芩颗粒可以有效缓解临床症状,减轻神经源性炎症,疗效显著,其机制值得进一步研究。Objective:To observe the clinical efficacy and related mechanism of Chanqin Granule in treatment of post-infectious cough of wind-phlegm lingering Lung syndrome.Methods:85 patients with post-infectious cough were randomly divided into the Chanqin Granule group(n=43)and the Asmeton group(n=42).The course of treatment was 14 days.The symptom score,the cough remission time,the HARQ airway reflux meter score,and the levels of SP and IL-6 were compared between the two groups after the treatment.Results:The scores of cough and pharyngeal itch were lower in the Chanqin Granule group than those in the Asmeton group(P<0.05);the cough remission time of the Chanqin Granule group was shorter than that of the Asmeton group.The occurrence rates of short of breath,aversion to wind,chest tightness,dry mouth and hard stool were decreased in the Chanqin Granule group(P<0.05).The HARQ score of Chanqin granule group decreased gradually with the extension of treatment time.The levels of SP and IL-6 were lower after the treatment than those before the treatment in the two groups(P<0.05).Conclusion:Chanqin Granule can effectively alleviate clinical symptoms and neurogenic inflammation.It has a significant curative effect and is worthy of further study.
关 键 词:蝉芩颗粒 风痰恋肺证 感染后咳嗽 气道神经源性炎症
分 类 号:R256.1[医药卫生—中医内科学]
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