2016-2020年辽宁省肾综合征出血热监测结果分析  

Surveillance results of hemorrhagic fever with renal syndrome in Liaoning,2016-2020

作　　者：张洁[1] 刘学升[1] 王子江[1] 徐晓婷[1] 毛玲玲[1] 孙英伟[1] Zhang Jie;Liu Xuesheng;Wang Zijiang;Xu Xiaoting;Mao Lingling;Sun Yingwei(Liaoning Provinc center for Disease Control and Prevention,Shenyang 110005,Liaoning,China)

机构地区：[1]辽宁省疾病预防控制中心,辽宁沈阳110005

出　　处：《疾病监测》2022年第11期1458-1461,共4页Disease Surveillance

基　　金：国家科技重大专项(No.2017ZX10103007)。

摘　　要：目的分析辽宁省肾综合征出血热(HFRS)流行特征和变化趋势,为制定防控措施提供科学依据。方法收集中国传染病监测信息系统报告的2016—2020年辽宁省HFRS疫情数据和人口资料,采用巢式反转录聚合酶链式反应和酶联免疫吸附试验对所选样本进行基因分型和抗体水平检测,通过描述流行病学方法,分析辽宁省HFRS时间、地区、人群发病的变化情况。结果2016—2020年辽宁省HFRS年平均发病率为1.98/10万(1.05/10万~2.53/10万),年平均死亡率为0.0064/10万。病例主要集中在西部地区的葫芦岛市、锦州市、朝阳市以及东部地区的铁岭市、抚顺市和本溪市。HFRS春夏峰(2—6月)和秋冬峰(10—12月)占总报告病例的79.78%。辽西地区葫芦岛市、锦州市、朝阳市、盘锦市、阜新市只有1个发病春夏峰,丹东市、鞍山市、辽阳市只有1个秋冬峰,抚顺市、铁岭市、本溪市秋冬峰高于春夏峰,大连市、营口市、沈阳市春夏峰高于秋冬峰。人群分布上男女性别比为2.51∶1,以农民为主,25~69岁年龄组占87.40%,隐性感染率为5.50%。各市汉坦病毒基因型分布呈现不同特点,辽西地区5市只检出汉城(SEOV)型病毒;其他9个地市均检出SEOV型和汉滩(HTNV)型病毒。结论2016—2020年辽宁省HFRS发病率呈小幅波动;辽宁省为HTNV型和SEOV型病毒的混合疫区,优势型病毒流行的季节性表现较为明显,不同地区HFRS流行特征差异显著,应制定有针对性的防控措施。Objective To analyze the epidemiological characteristics and change trend of hemorrhagic fever with renal syndrome(HFRS)in Liaoning province and provide scientific basis for the development of prevention and control measures.Methods The incidence data of HFRS and population data in Liaoning from 2016 to 2020 were collected from China Infectious Disease Surveillance Information System.Gene typing and antibody level of the selected samples were detected by nested RT-PCR and enzyme-linked immunosorbent assay(ELISA).The dynamic characteristics of monthly,regional and population distribution of HFRS in Liaoning were analyzed by descriptive epidemiological method.Results From 2016 to 2020,the annual average incidence rate of HFRS in Liaoning was 1.98/100000,the incidence rate fluctuated between 1.05/100000 and 2.53/100000,and the annual average mortality rate was 0.0064/100000.The cases were mainly occurred in Huludao,Jinzhou and Chaoyang in western Liaoning and Tieling,Fushun and Benxi in eastern Liaoning.The incidence peak of HFRS was during spring-summer(February-June)and during autumn-winter(October-December),the cases accounted for 79.78% of the total reported cases.There was only one incidence peak during spring-summer in Huludao,Jinzhou,Chaoyang,Panjin and Fuxin,only one incidence peak during autumn-winter in Dandong,Anshan and Liaoyang,the autumn winter peak was higher than the spring summer peak in Fushun,Tieling and Benxi,and the spring summer peak was higher than the autumn winter peak in Dalian,Yingkou and Shenyang.In terms of population distribution,the male to female ratio of the cases was 2.51∶1,the cases were mainly farmers.The cases in age group of 25-69 years old accounted for 87.40%,and the recessive infection rate was 5.50%.The distribution of hantavirus genotypes in different areas showed different characteristics.Only Seoul genotype was detected in 5 areas in western Liaoning;Seoul genotype and Hantan genotype were detected in other 9 areas.Conclusion The incidence rate of HFRS in Liaoning fluct

关 键 词：肾综合征出血热 监测 辽宁省 

分 类 号：R211[医药卫生—中医学] R181R183.5