高毒力肺炎克雷伯菌毒力和耐药机制研究进展  

Progress in research of virulence and drug resistance mechanism of hypervirulent Klebsiella pneumonia

作　　者：周君辰 李娟[2] 周海健[2] 邢欢 董爱英 Zhou Junchen;Li Juan;Zhou Haijian;Xing Huan;Dong Aiying(North China University of Science and Technology,Tangshan 063000,Hebei,China;State Key Laboratory for Infectious Disease Prevention and Control,National Institute for Communicable Disease Control and Prevention,Chinese Center for Disease Control and Prevention,Beijing 102206,China)

机构地区：[1]华北理工大学附属医院,河北唐山063000 [2]中国疾病预防控制中心传染病预防控制所,传染病预防控制国家重点实验室,北京102206

出　　处：《疾病监测》2022年第11期1474-1477,共4页Disease Surveillance

基　　金：中国煤炭工业协会2018年度科学技术研究指导性计划项目(No.MTKJ2018-267);河北省卫生健康委科研基金项目(No.20191146)。

摘　　要：肺炎克雷伯菌属于克雷伯菌属中需氧革兰阴性杆菌,是社区获得性感染和院内感染常见致病菌之一。高毒力肺炎克雷伯菌(hypervirulent Klebsiella pneumoniae,hvKP)是从传统肺炎克雷伯菌中分离出来的具有高毒力、高黏液性的侵袭性细菌,当机体免疫功能降低时,可引起肺炎、肝脓肿、泌尿系统感染和血流感染,严重时还可导致脓毒血症等危急重症,治疗难度大且病死率高。为更好地了解hvKP特性,对其流行现状、高毒力相关因子、耐药以及相关机制等进行综述,以助于临床更好地预防和控制hvKP感染。Klebsiella pneumoniae is a gram-negative pathogen belonging to the Klebsiella species,which is one of the common pathogens of community-acquired infection and nosocomial infection.Hypervirulent K.pneumoniae(hvKP)is a highly virulent,highly viscous invasive bacteria isolated from traditional K.pneumoniae.hvKP can cause pneumonia,liver abscess,urinary tract infection and bloodstream infection and even sepsis when the immune function of the body is reduced.The infection is difficult to treat and the case fatality is high.For better the understanding of the characteristics of hvKP,this paper summarizes the spread status,high virulence related factors,drug resistance and related mechanisms of hvKP to facilitate the prevention and control of hvKP infection in clinical practice.

关 键 词：高毒力肺炎克雷伯菌 流行现状 毒力因子 耐药机制 

分 类 号：R211[医药卫生—中医学] R446.5