菊苣酸抗病毒及抗菌作用研究进展  

Antiviral and Antibacterial Effect of Chicoric Acid:A Review

作　　者：吴超[1,2] 李俊强 丛晓娟 高源 于飞 吕艳羽 杨敏 李健[4] 冯帅[1,5] 李峰[1] WU Chao;LI Junqiang;CONG Xiaojuan;GAO Yuan;YU Fei;LYU Yanyu;YANG Min;LI Jian;FENG Shuai;LI Feng(Shandong Universityof Traditional Chinese Medicine(TCM),Jinan 250355,China;Shandong Drug and Food Vocational College,Weihai 264210,China;Yantai Center forFood and Drug Control,Yantai 264000,China;Affiliated Hospital of Shandong University of TCM,Jinan 250355,China;Shandong Collaborative Innovation Center for TCM Quality Control and Construction of Whole Industrial Chain,Jinan 250355,China)

机构地区：[1]山东中医药大学,济南250355 [2]山东药品食品职业学院,山东威海264210 [3]烟台市食品药品检验检测中心,山东烟台264000 [4]山东中医药大学附属医院,济南250355 [5]山东省高校中药质量控制与全产业链建设协同创新中心,济南250355

出　　处：《中国实验方剂学杂志》2022年第24期220-228,共9页Chinese Journal of Experimental Traditional Medical Formulae

基　　金：国家自然科学基金项目(82004233);山东省自然科学基金项目(ZR2021QH111);国家“重大新药创制”科技重大专项(2017ZX09301058);山东省医药卫生科技发展计划项目(202013030996);全国名老中医药专家传承工作室建设项目(国中医药人教函[2022]75号)。

摘　　要：菊苣酸是一种羟基肉桂酸,分子式为C_(22)H_(18)O_(12),为蒲公英、紫锥菊、菊苣等多种天然植物中的重要活性成分,其有助于植物保护自身免受昆虫侵害及病毒、细菌、真菌和线虫的感染。现代药理学研究表明,菊苣酸在抗炎、抗氧化、调节免疫、抗菌、抗病毒、抗肿瘤等方面具有显著的生物活性。菊苣酸首次被报道的生物活性是其对人类免疫缺陷病毒的抑制作用,随着分子生物学相关技术的发展与应用,菊苣酸对其他病毒的抑制活性及作用机制被不断报道;另有研究表明菊苣酸对不同致病菌也有显著抑制作用。该文通过汇总近20年来国内外相关文献,全面综述了菊苣酸在抗病毒及抗菌方向的研究进展,研究表明菊苣酸对人类免疫缺陷病毒、乙型肝炎病毒、呼吸道合胞病毒、单纯疱疹病毒等多种病毒,以及金黄色葡萄球菌、小肠结肠炎耶尔森菌、结核分枝杆菌等不同致病菌均具有显著的抑制活性,该文旨在为菊苣酸抗病原微生物感染的深入研究及中医药抗病毒与抗菌研究提供参考。Chicoric acid,a hydroxycinnamic acid with the molecular formula C_(22)H_(18)O_(12),is an importan active ingredient in Taraxacum mongolicum,Echinacea purpurea,Cichorium intybus and other natural plants,and it helps plants protect themselves from insects and infection from viruses,bacteria,fungi,and nematodes.Modern pharmacological research suggests that chicoric acid has significant bioactivities such as antiinflammatory,antioxidant,immune-regulating,antibacterial,antiviral and anti-tumor properties.The first reported bioactivity of chicoric acid is its inhibitory effect on human immunodeficiency virus(HIV).With the development and application of molecular biology and related technologies,the inhibitory activities of chicoric acid on other viruses as well as its mechanism of action have been frequently reported.Another study indicates that chicoric acid has significant inhibitory effects on different pathogenic bacteria.This paper summarized the research progress on the antiviral and antibacterial effects of chicoric acid through a comprehensive review of relevant literature in China and abroad in the past 20 years.Studies have shown that chicoric acid has significant inhibitory activities against various viruses such as HIV,hepatitis B virus(HBV),respiratory syncytial virus(RSV),and herpes simplex virus(HSV),as well as different pathogenic bacteria such as Staphylococcus aureus,Yersinia enterocolitica and Mycobacterium tuberculosis.This study is expected to provide references for in-depth research on chicoric acid against pathogenic microorganisms and antiviral and antibacterial study of traditional Chinese medicine.

关 键 词：菊苣酸 抗病毒作用 抗菌作用 研究进展 

分 类 号：R2-0[医药卫生—中医学] R33[文化科学—情报学] G353.11R978.7