脂肪酸对诱导多能干细胞分化成熟为心肌细胞的影响进展  

Research progress on effects of fatty acids on differentiation and maturation of induced pluripotent stem cells into cardiomyocytes

作　　者：高桢 周帆 穆军升[1] Gao Zhen;Zhou Fan;Mu Junsheng(Department of Cardiac Surgery,Beijing Anzhen Hospital,Capital Medical University,Beijing Institute of Heart Lung and Blood Vessel Diseases,Beijing 100029,China;Department of Ultrasound,the Third Medical Center of People′s Liberation Army of China General Hospital,Beijing 100039,China)

机构地区：[1]首都医科大学附属北京安贞医院心脏外科-北京市心肺血管疾病研究所,100029 [2]解放军总医院第三医学中心超声科,北京100039

出　　处：《中华实验外科杂志》2022年第11期2285-2288,共4页Chinese Journal of Experimental Surgery

基　　金：2018年国家自然科学基金(81870181);中国科协2021年度公共服务能力提升项目立项(2021GGFW003);2022年国家自然科学基金(82270255)。

摘　　要：近年来,心血管疾病的发病率呈现持续增长的趋势,而心血管的发病年龄也逐年下降,而心肌细胞作为人体内为数不多不可再生的细胞,对于诱导多能干细胞分化成熟为心肌细胞的研究对于心脏疾病的治疗和研究有着不可估量的作用,在细胞学层面对心血管疑难杂症进行定向治疗。而对于多能干细胞分化成熟为心肌细胞的过程来说,无论是对于细胞的代谢、细胞器的发育、特定基因的表达以及特定功能的发挥,脂肪酸有着很大的影响作用。本文旨在阐述近年来国内外对于脂肪酸对诱导多功能干细胞分化成熟为心肌细胞影响的研究进展。In recent years,the incidence of cardiovascular disease shows a continuous increase,and the age of cardiovascular morbidity is also decreasing year by year,As cardiomyocytes are one of the few non-renewable cells in the human body,the research on inducing pluripotent stem cells to differentiate and mature into cardiomyocytes has an invaluable role in the treatment and research of heart diseases.This study could also contribute to the study of cardiac repair and the targeted treatment of difficult cardiovascular diseases at cytological level.And for the process of differentiation and maturation of pluripotent stem cells into cardiomyocytes,Fatty acids have a strong influence on cellular metabolism,organelle development,expression of specific genes and the performance of specific functions.The purpose of this paper is to describe the recent progress of research on the effect of fatty acids on inducing multifunctional stem cells to differentiate and mature into cardiomyocytes in China and abroad.

关 键 词：脂肪酸 诱导多能干细胞 心肌细胞 心血管疾病 

分 类 号：R54[医药卫生—心血管疾病]