血压水平及其组合对金昌队列人群脑卒中发病影响  

Effect of blood pressure on stroke incidence among Jinchang Cohort participants

作　　者：许璐璐 王玉峰 沈淑娟 陈亚荣 胡雨佳 李靖 李思宇 白亚娜[1] XU Lu-lu;WANG Yu-feng;SHEN Shu-juan(Institute of Epidemiology and Health Statistics,School of Public Health,Lanzhou University,Lanzhou,Gansu Province 730000,China;不详)

机构地区：[1]兰州大学公共卫生学院流行病与卫生统计学研究所,甘肃兰州730000 [2]金川公司职工医院

出　　处：《中国公共卫生》2022年第10期1274-1278,共5页Chinese Journal of Public Health

基　　金：金川集团公司职工代谢性疾病全程管理体系建设(金科综2020-02)。

摘　　要：目的了解血压水平及其不同组合对金昌队列人群脑卒中发病的影响,为人群血压管理和脑卒中的防控提供参考依据。方法收集金昌队列2011年6月—2015年12月完成基线调查和随访调查的32736名金昌队列人群的相关数据,应用单因素和多因素Cox比例风险回归模型分析不同血压水平及其组合对脑卒中发病风险的影响。结果金昌队列人群随访期间脑卒中发病率为0.88%,男性和女性人群发病率分别为1.03%和0.65%。调整性别、年龄、文化程度、吸烟情况、饮酒情况、有无糖尿病和脑卒中家族史等混杂因素后,多因素Cox比例风险回归分析结果显示,金昌队列人群收缩压为120~139、140~159和≥160 mm Hg时发生脑卒中的风险分别为<120 mm Hg时的1.53、2.65和3.09倍,舒张压为80~89、90~99和≥100 mm Hg时发生脑卒中的风险分别为<80 mm Hg时的1.42、2.17和2.79倍;收缩压/舒张压为120~139/80~89、140~159/<80、140~159/80~89、140~159/90~99、140~159/≥100、≥160/<100和≥160/≥100 mm Hg时发生脑卒中的风险分别为<120/<80 mm Hg时的1.83、2.55、1.81、3.21、3.34、2.28和3.97倍。在调整了年龄、文化程度、吸烟情况、饮酒情况、有无糖尿病和有无脑卒中家族史等混杂因素后,多因素Cox回归分析结果显示,金昌队列男性人群收缩压为140~159和≥160 mm Hg时发生脑卒中的风险分别为<120 mm Hg时的2.44和2.86倍,舒张压为90~99和≥100 mm Hg时发生脑卒中的风险分别为<80 mm Hg时的2.02和2.95倍;金昌队列女性人群收缩压为120~139、140~159和≥160 mm Hg时发生脑卒中的风险分别为<120 mm Hg时的2.03、2.55和2.83倍,舒张压为90~99 mm Hg时发生脑卒中的风险为<80 mm Hg时的2.34倍。结论不同血压水平及其组合金昌队列人群脑卒中发病风险不同,在血压管理和脑卒中的防控工作中应予以综合考量。Objective To examine effects of systolic blood pressure(SBP)/diastolic blood pressure(DBP)on the incidence of stroke among in-service workers and retirees enrolled in a study conducted at the Jinchuan Nonferrous Metals Corporation located in Jinchang city of Gansu province(Jinchang Cohort)for providing references for blood pressure control and stroke prevention in the population.Methods The study included 32736 Jinchang Cohort participants with completed information of baseline survey in June 2011 and follow-up study in December 2015.Univariate and multivariate Cox proportional hazards model were used to analyze the effect of SBP/DBP(in mm Hg)measured at the baseline survey on the risk of stroke incidence in the population.Results During the follow-up period,the incidence of stroke was 0.88%for all the participants and the incidence was 1.03%for 19879 males aged 46.24±13.40 years and 0.65%for 12857 females aged45.89±11.36 years,respectively.After adjusting for gender,age,education,smoking,alcohol drinking,and family history of diabetes and stroke,the results of multivariate Cox regression analysis showed that compared to those with the SBP of lower than 120,the participants with the SBP of 120–139(except for the males),140–159,and≥160 were at a significantly increased risk of stroke,with the hazard risk(HR)of 1.53(2.03 for females),2.65(2.44 for males and 2.55 for females),and3.09(2.86 for males and 2.83 for females);compared to those with the DBP of lower than 80,the participants with the DBP of 80–89(only for all the participants as a whole),90–99,and≥100 were at a significantly increased risk of stroke,with the HR of 1.42,2.17(2.02 for males and 2.34 for females),and 2.79(2.95 for males and 1.94 for females);in contrast to those with the SBP/DBP of<120/<80,the HR of stroke incidence was 1.83 for the participants with the SBP/DBP of 120–139/80–89,2.55 for 140–159/<80,1.81 for 140–159/80–89,3.21 for 140–159/90–99,3.34 for 140–159/≥100,2.28for≥160/<100,and 3.97 for≥160/≥100,r

关 键 词：血压水平 组合 金昌队列人群 脑卒中 影响 

分 类 号：R181.1[医药卫生—流行病学] R743[医药卫生—公共卫生与预防医学]