中医药治疗慢性心衰的新靶标:肠道微生态  

Intestinal Microecology:A New Target of Chinese Medicine for Chronic Heart Failure

作　　者：吕仕超[1] 贾秋瑾 张晓囡 丁越佳 张军平[1] LÜShi-chao;JIA Qiu-jin;ZHANG Xiao-nan;DING Yue-jia;ZHANG Jun-ping(First Teaching Hospital of Tianjin University of Traditional Chinese Medicine,National Clinical Research Center for Chinese Medicine Acupuncture and Moxibustion,Tianjin 300391)

机构地区：[1]天津中医药大学第一附属医院,国家中医针灸临床医学研究中心,天津300193

出　　处：《中国中西医结合杂志》2022年第11期1387-1391,共5页Chinese Journal of Integrated Traditional and Western Medicine

基　　金：中华中医药学会青年人才托举工程(No.CACM-2018-QNRC2-B04);天津市卫生计生行业高层次人才选拔培养工程(No.津人才[2017]18号)。

摘　　要：慢性心力衰竭(简称慢性心衰)是心血管疾病的晚期阶段,其患病率、病死率和再住院率居高不下,给社会带来了沉重的经济负担,是最重大的公共卫生问题之一。近年来,肠道微生态的研究迅速发展,为揭示疾病的发生规律和药物的效应机制提供了全新的视角。中医药治疗慢性心衰具有独特优势。以肠道微生态为靶标,诠释中医药防治慢性心衰的科学内涵,可能再次更新慢性心衰的治疗理念,从而提高慢性心衰的治疗效果。Chronic heart failure(HF)is the advanced stage of cardiovascular disease.Its high prevalence,mortality rate and rehospitalization rate bring a heavy economic burden to society and is one of the most important public health problems.Since the start of human microbiome project,the research of intestinal microecology has developed rapidly,which provides a new perspective for revealing the occurrence of diseases and the mechanism of drug effect.Chinese medicine has unique advantages in treating chronic HF.From the perspective of intestinal microecology,the scientific connotation of Chinese medicine in the treatment of chronic HF may be interpreted,and the treatment concept of chronic HF may be renewed again,so as to improve the treatment effect of chronic HF.

关 键 词：慢性心力衰竭 肠道菌群 氧化三甲胺 短链脂肪酸 中医药 

分 类 号：R259[医药卫生—中西医结合]