肺力咳合剂联合雾化吸入布地奈德混悬液治疗小儿急性支气管炎的疗效及对血清急性时相蛋白和免疫球蛋白的影响  

Effect of Feilike Mixture Combined with Aerosol Inhalation of Budesonide Suspension on Acute Bronchitis in Children and its Effect on Serum Acute Phase Protein and Immunoglobulin

作　　者：吴新婷 孟远翠 郑玲芳[1] 杨艳娥[1] 范静华[1] WU Xin-ting;MENG Yuan-cui;ZHENG Ling-fang;YANG Yan-e;FAN Jing-hua(Department of Pediatrics,The Second Affiliated Hospital of Xi’an Medical College,Xi'an,Shaanxi,710038,China)

机构地区：[1]西安医学院第二附属医院儿科,陕西西安710038

出　　处：《现代生物医学进展》2022年第22期4316-4319,4325,共5页Progress in Modern Biomedicine

基　　金：陕西省合作计划项目(S2016YFKW0073)。

摘　　要：目的:观察肺力咳合剂联合雾化吸入布地奈德混悬液治疗急性支气管炎患儿的疗效及对血清急性时相蛋白和免疫球蛋白的影响。方法:选取2016年1月到2021年12月期间在西安医学院第二附属医院进行治疗的120例急性支气管炎患儿,按照随机数字表法分为对照组(接受雾化吸入布地奈德混悬液治疗,n=60)和研究组(肺力咳合剂联合雾化吸入布地奈德混悬液治疗,n=60),对比两组疗效、用药不良反应情况,观察两组患儿临床症状缓解时间,观察两组患儿血清急性时相蛋白和免疫球蛋白的变化情况。结果:研究组的临床总有效率相较于对照组,可进一步升高,组间对比差异有统计学意义(P<0.05)。研究组的呼吸困难、咳嗽、肺部喘鸣、憋喘症状消失时间均短于对照组(P<0.05)。治疗后,两组触珠蛋白(HP)、C反应蛋白(CRP)、a1酸性糖蛋白(a1-AAG)和铜蓝蛋白(CER)水平均下降,且研究组低于对照组(P<0.05)。治疗后,两组免疫球蛋白A(Ig A)、免疫球蛋白M(Ig M)、免疫球蛋白G(Ig G)均升高,且研究组较对照组高(P<0.05)。两组不良反应发生率对比无差异(P>0.05)。结论:肺力咳合剂联合雾化吸入布地奈德混悬液治疗急性支气管炎患儿,可有效改善体液免疫,降低患儿血清急性时相蛋白,疗效显著。Objective:To observe the curative effect of feilike mixture combined with aerosol inhalation of budesonide suspension on acute bronchitis in children and its effect on serum acute phase protein and immunoglobulin.Methods:120 children with acute bronchitis who were treated in our hospital from January 2016 to December 2021 were randomly selected,they were divided into control group(treated with atomized budesonide suspension,n=60)and study group(treated with Feilike mixture combined with atomized budesonide suspension,n=60).The curative effects and adverse drug reactions of the two groups were compared,and the remission time of clinical symptoms of the two groups was observed.The changes of serum acute phase protein and immunoglobulin in the two groups were observed.Results:Compared with the control group,the total clinical effective rate of the study group could be further increased,and the difference between the groups was statistically significant(P<0.05).The disappearance time of dyspnea,cough,pulmonary wheezing and wheezing symptoms in the study group was shorter than that in the control group(P<0.05).After treatment,the levels of haptoglobin(HP),C-reactive protein(CRP),a1 acid glycoprotein(a1 AAG)and ceruloplasmin(CER)in the two groups were decreased,and the study group was lower than those in the control group(P<0.05).After treatment,immunoglobulin A(Ig A),immunoglobulin M(Ig M)and immunoglobulin G(Ig G)increased in both groups,and the study group was higher than the control group(P<0.05).There was no difference in the incidence of adverse reactions between the two groups(P>0.05).Conclusion:Feilike mixture combined with aerosol inhalation of budesonide suspension can effectively improve humoral immunity and reduce serum acute phase protein in children with significant curative effect.

关 键 词：肺力咳合剂 雾化吸入 布地奈德混悬液 急性支气管炎患儿 疗效 急性时相蛋白 免疫球蛋白 

分 类 号：R562.2[医药卫生—呼吸系统]