光纤光声血氧饱和度测量与功能成像  

Optical Fiber Photoacoustic Blood Oxygen Saturation Measurement and Functional Imaging

作　　者：付武兵 梁贻智 仲晓轩 黄杰 金龙 关柏鸥 Fu Wubing;Liang Yizhi;Zhong Xiaoxuan;Huang Jie;Jin Long;Guan Baiou(Guangdong Provincial Key Laboratory of Optical Fiber Sensing and Communications,Institute of Photonics Technology,Jinan University,Guangzhou 510632,Guangdong,China)

机构地区：[1]暨南大学光子技术研究院广东省光纤传感与通信技术重点实验室,广东广州510632

出　　处：《光学学报》2022年第20期125-134,共10页Acta Optica Sinica

基　　金：国家自然科学基金(61860206002,62122031);广东珠江团队项目(2019BT02X105);广东省科技计划(2020A0505100044,2020A0505140005);广州市科技计划(201904020032)。

摘　　要：光声功能成像利用动静脉血在光学吸收谱上的差异,通过多波长光声激发与探测来获得生物组织内血氧饱和度的空间分布,为医学研究与疾病诊断提供了重要的功能信息。受限于压电传感器的超声探测灵敏度,小型化光声成像技术的血氧饱和度测量误差大,功能成像能力难以满足医学需求。针对这一问题,提出利用分布反馈布拉格光纤激光器作为敏感元件对微弱光声信号进行探测,利用两正交激光模式之间的拍频来读取超声引起的扰动。通过光学放大有效克服激光器的频率噪声,从而获得活体脑组织和直肠内壁血管的高空间分辨率的功能成像结果。Based on the differences of arteriovenous blood in the optical absorption spectrum,photoacoustic functional imaging obtains the spatial distribution of blood oxygen saturation in biological tissues by multi-wavelength photoacoustic excitation and detection,which provides important functional information for medical research and disease diagnosis.However,limited by the ultrasonic detection sensitivity of piezoelectric sensors,miniaturized photoacoustic imaging technology has a large error in the measurement of blood oxygen saturation,and the functional imaging capability is difficult to meet medical requirements.To address this problem,a distributed feedback Bragg fiber laser is considered as a sensitive element to detect weak photoacoustic signals,and the perturbation caused by ultrasound is read by the beat frequency between two orthogonal laser modes.The frequency noise of the laser is effectively suppressed by optical amplification,and thus the high-spatial-resolution functional imaging results of in vivo brain tissues and blood vessels in the rectum lining are obtained.

关 键 词：医用光学 光声成像 血氧饱和度 光纤传感器 信噪比 

分 类 号：R319[医药卫生—基础医学] TH744[机械工程—光学工程]