Cancer genes and cancer stem cells in tumorigenesis:Evolutionary deep homology and controversies  

作　　者：Vladimir F.Niculescu 

机构地区：[1]Kirschenweg 1,Diedorf 86420,Germany

出　　处：《Genes & Diseases》2022年第5期1234-1247,共14页基因与疾病（英文）

摘　　要：In the past,contradictory statements have been made about the age of cancer genes.While phylostratigraphic studies suggest that cancer genes emerged during the transitional period from unicellularians(UC)to early metazoans(EM),life cycle studies suggest that they arose earlier.This controversy could not be resolved.Phylostratigraphic methods use data from somatic tumor gene collections containing or lacking polyploidy genes(PGCC genes)and compare them to genes from evolutionary node taxa.I analyze whether the selected taxa are suitable to resolve the above contradiction or not.Both cancer and amoebae life cycles have a reproductive asexual germline that produces germline stem cells(GSCs)and somatic cell lines that cannot.When the germline loses its reproductive function,the soma-to-germ transition forms a new reproductive germline.The reproductive polyploidy of cancer is homologous to the reproductive polyploidy of unicellular cysts.PGCCs repair DNA defects,reorganize the involved genome architecture and produce new GSCs.The present study refutes the dogma of the early metazoan origin of cancer.Cancer has a unicellular life cycle that was adopted by early metazoans to rescue themselves from evolutionary dead ends.Early metazoans controlled the unicellular life cycle through suppressor and anti-suppressor genes that could suspend or reactivate it.They are the archetypes of tumor suppressor genes and oncogenes.Cells of mammalians and humans that reach a similar impasse as early metazoans can reactivate the conserved life cycle of unicellularians.

关 键 词：Cancer ENTAMOEBA Gene age Life cycle POLYPLOIDY CSCs EMT PGCC 

分 类 号：R329.2[医药卫生—人体解剖和组织胚胎学]