Structural insights into the Omicron spike trimer:tackling the challenges of continuously evolving SARS-CoV-2 variants  

作　　者：Junxian Ou Jianguo Wu Qiwei Zhang 

机构地区：[1]Guangdong Provincial Key Laboratory of Virology,Institute of Medical Microbiology,Jinan University,510632 Guangzhou,China

出　　处：《Signal Transduction and Targeted Therapy》2022年第10期3625-3627,共3页信号转导与靶向治疗（英文）

基　　金：supported by grants from the National Key Research and Development Program of China(2018YFE0204503);National Natural Science Foundation of China(32170139 and 81730061);Natural Science Foundation of Guangdong Province(2021A1515010788 and 2022A1515011190);the Fundamental Research Funds for the Central Universities(21622101).

摘　　要：The recent studies published in Science and Cell Research investigated the structures and biochemical mechanism of the SARS-CoV-2 Omicron BA.1 and BA.2 spike trimer with ACE2 as well as an effective antibody JMB2002 against BA.1 and BA.2 spike,which provide new insights for the global development of broadspectrum anti-SARS-CoV-2 antibodies and vaccines.

关 键 词：ACE2 INSIGHT continuously 

分 类 号：R563.1[医药卫生—呼吸系统]