Omicron spike protein:a clue for viral entry and immune evasion  

作　　者：G.M.N.Behrens A.Cossmann M.Hoffmann 

机构地区：[1]Department for Rheumatology and Immunology,Hannover Medical School,Hannover,Germany [2]German Centre for Infection Research,partner site Hannover-Braunschweig,Hannover,Germany [3]CiiM,Centre for Individualized Infection Medicine,Hannover,Germany [4]Infection Biology Unit,German Primate Center,Göttingen 37077,Germany [5]Faculty of Biology and Psychology,Georg-August-University Göttingen,Göttingen,Germany

出　　处：《Signal Transduction and Targeted Therapy》2022年第10期3639-3640,共2页信号转导与靶向治疗（英文）

基　　金：supported by the German Center for Infection Research(grant no.80018019238,TTU-HIV 04.821,and 04.820);a European Regional Development Fund(ZW7-8515131,ZW7-85151373).

摘　　要：In a recent study in Science,Bowen et al.1 report that mutations in Omicron sublineage’s spike protein enhance ACE2 binding,impair fusogenicity,and dampen the neutralizing activity of antibodies after vaccination or infection.The data describe how Omicron and especially the BA.5 variant evade neutralizing antibody responses and argue for using mRNA booster vaccination to increase immunity.

关 键 词：ACE2 BOWEN al. 

分 类 号：R392[医药卫生—免疫学]