群体感应调控细菌耐药的机制  

Mechanisms of quorum sensing regulating antimicrobial resistance

作　　者：夏乐欣 周慧 徐峰[1] Xia Lexin;Zhou Hui;Xu Feng(Department of Infectious Diseases,Second Affiliated Hospital,Zhejiang University School of Medicine,Hangzhou 310009,China)

机构地区：[1]浙江大学医学院附属第二医院感染性疾病科,杭州310009

出　　处：《中华结核和呼吸杂志》2022年第12期1260-1266,共7页Chinese Journal of Tuberculosis and Respiratory Diseases

基　　金：国家自然科学基金(81970004,82200052);浙江大学滨江研究院项目(ZY202205SMKY006)。

摘　　要：细菌的抗菌素耐药已成为威胁人类健康的重大问题,亟需新策略阻控细菌耐药。群体感应是微生物细胞间交流的一种机制,当环境中群体密度达到阈值后群体感应即被激活,调控下游基因转录。群体感应已被证实可调控生物膜、外排泵、细菌分泌系统等抗菌素耐药机制,有望成为耐药调控靶点。目前已有多种群体感应抑制剂通过降解信号分子、干扰信号分子与受体蛋白的识别和结合、阻断群体感应信号的合成等方式干扰群体感应。群体感应抑制剂有望成为阻控微生物耐药的新方法。Antimicrobial resistance is a major threat to human health,so new strategies are urgently needed to impede antimicrobial resistance.Quorum sensing is an intracellular communication system that is activated to regulate downstream gene transcription when the population density reaches a threshold.Quorum sensing regulates drug resistance by altering biofilm formation and dispersion,efflux pump expression,and bacterial secretion systems,making it a promising target of overcoming antimicrobial resistance.To date,various quorum sensing inhibitors have been found to block quorum sensing by degrading signal molecules,interfering with the recognition and binding of signal molecules and receptors,and interrupting the synthesis of quorum sensing signals.Hence,quorum sensing inhibitors are expected to become a new way to control antimicrobial resistance.

关 键 词：细菌耐药 群体感应 群体密度 受体蛋白 耐药机制 分泌系统 抗菌素 生物膜 

分 类 号：R378[医药卫生—病原生物学]