姜黄中一个新颖的倍半萜成分  

A novel sesquiterpenoid from Curcuma longa L.

作　　者：李泊雨 彭成[1] 舒洪珍 刘菲 熊亮[1,2] LI Bo-yu;PENG Cheng;SHU Hong-zhen;LIU Fei;XIONG Liang(State Key Laboratory of Characteristic Chinese Medicine Resources in Southwest China,School of Pharmacy,Chengdu University of Traditional Chinese Medicine,Chengdu 611137,China;Institute of Innovative Medicine Ingredients of Southwest Specialty Medicinal Materials,Chengdu University of Traditional Chinese Medicine,Chengdu 611137,China)

机构地区：[1]成都中医药大学药学院,西南特色中药资源国家重点实验室,四川成都611137 [2]成都中医药大学,西南特色药材创新药物成分研究所,四川成都611137

出　　处：《药学学报》2022年第12期3603-3607,共5页Acta Pharmaceutica Sinica

基　　金：国家自然科学基金优秀青年基金资助项目(82022072);国家自然科学基金青年基金资助项目(81903777)。

摘　　要：采用硅胶柱色谱、中压液相色谱、半制备高效液相色谱等分离技术,从姜黄95%乙醇提取物中分离得到1个新化合物。结合质谱、核磁、计算ECD等手段确定了化合物的结构及绝对构型,发现化合物为一个结构新颖的倍半萜类成分,将其命名为isoturmeronol B(1)。化合物1的骨架与没药烷型倍半萜相似,唯一区别在于化合物1在没药烷型倍半萜骨架的基础上,C-4位的甲基迁移至C-5位。对化合物1的抗炎和抗氧化活性进行了评价,结果表明化合物1无抗炎及抗氧化活性。A new compound was isolated from the 95% ethanolic extract of the rhizomes of Curcuma longa L.using silica gel column chromatography,medium pressure liquid chromatography,and semi-preparative high performance liquid chromatography.The structure and absolute configuration of the compound was elucidated by HR-ESI-MS,NMR,and electronic circular dichroism(ECD) calculations.It is a novel sesquiterpenoid,which is named as isoturmeronol B(1).The carbon skeleton of compound 1 is similar to that of bisabolane-type sesquiterpenoid.The only difference is that the methyl group at C-4 in bisabolene-type sesquiterpenoid is migrated to C-5 in compound 1.Besides,the anti-inflammatory and antioxidant activities of the compound 1 were evaluated.The results showed that 1 has no anti-inflammatory and antioxidant activities.

关 键 词：姜黄 分离鉴定 新化合物 绝对构型 倍半萜 

分 类 号：R284[医药卫生—中药学]