PTHrP⁃HDAC4/Ihh信号通路在生长板发育中调控作用的研究进展  

Research advances in the regulation of PTHrP⁃HDAC4/Ihh signaling pathway during growth plate development

作　　者：宗素静 郝宇 黄凌岸 陈崇伟[2] Zong Sujing;Hao Yu;Huang Ling'an;Chen Chongwei(Department of Biochemistry,Basic Medical College,Shanxi Medical University,Taiyuan 030000,China;Department of Orthopedics,Second Hospital,Shanxi Medical University,Taiyuan 030001,China)

机构地区：[1]山西医科大学基础医学院生物化学与分子生物学教研室,030000 [2]山西医科大学第二医院骨科,030001

出　　处：《中华小儿外科杂志》2022年第11期1053-1056,F0003,共5页Chinese Journal of Pediatric Surgery

基　　金：国家自然科学基金面上项目(81871815);山西省自然科学基金面上项目(201701D121170);山西省回国留学人员科研资助项目(2017⁃063)。

摘　　要：甲状旁腺激素相关蛋白(parathyroid hormone⁃related protein,PTHrP)、组蛋白去乙酰化酶4(histone deacetylase 4,HDAC4)及印度刺猬蛋白(indian hedgehog,Ihh)对生长板软骨细胞的增殖、分化有重要的调控作用,上述基因的缺失在小鼠模型上均表现为短肢畸形。因此,对PTHrP⁃HDAC4/Ihh信号通路调控机制的研究可为治疗矮小症、侏儒症等软骨发育相关疾病提供临床新思路和干预新靶点。本综述主要总结近年来以该通路为主的相关因子对生长板发育调控机制的新进展,以期为儿童软骨发育相关疾病病理机制的深入研究提供新视角。Parathyroid hormone⁃related protein(PTHrP),histone deacetylase 4(HDAC4)and Indian hedgehog protein(Ihh)are essential in regulating the proliferation and differentiation of growth plate chondrocytes.And a deletion of these genes is manifested as short limb deformity in a murine model.Therefore understanding the regulatory mechanism of PTHrP⁃HDAC4/Ihh signaling pathway provide new clinical rationales and intervention targets for treating such cartilage development related diseases as short stature and dwarfism.This review summarized the latest advances in regulatory mechanism of growth plate development to provide new perspectives for an in⁃depth understanding of pathological mechanism of chondrogenesis related diseases in children.

关 键 词：甲状旁腺激素相关蛋白质 生长板 软骨细胞 

分 类 号：R726.8[医药卫生—儿科]