Efficacy of bronchoscopic thermal vapor ablation in patients with heterogeneous emphysema and lobar quantification by three-dimensional ventilation/perfusion single-photon emission computed tomography/computed tomography: a prospective pilot study from China  

作　　者：Wenjun Zhu Yuchen Zhang Felix J.F.Herth Dan Liu Hui Zhu Jingyu Shi Chujie Zhang Gongshun Tang Fengming Luo 

机构地区：[1]Department of Respiratory and Crical Care Medicine,West China Hospial,Sichuan University,Chengdu,Sichuan 610041,China [2]Laboratory of Pulmonary Immunology and Inflammation,Frontiers Science Center for Disease-Related Molecular Network,West China Hospital,Sichuan University,Chengdu Sichuan 610041,China [3]Department of Pneumology and Critical Care Medicine,Thoraxklik University of Heidelberg,Heidelberg,Germany [4]Department of Nuclear Medicine,West China Hospital,Sichuan University,Chengdu,Sichuan 610041,China

出　　处：《Chinese Medical Journal》2022年第17期2098-2100,共3页中华医学杂志（英文版）

基　　金：This work was supported by grants from the National Natural Science Foundationof China(NSFC No.81770072);the“1.3.5 project for disciplines of excellence,West China Hospital,Sichuan University(No.ZYJC18021)”;Chengdu Science and Technology Bureau(No.2018SZ0240).

摘　　要：Chronic obstructive pulmonary disease(COPD)is characterized by emphysema and airflow limitation and is one of the leading causes of morbidityand mortalityworldwide.Endoscopic lung volumereduction(ELVR)is a minimally invasive technique for patients with severe hyperinflation and advanced emphysema.To date,the most investigated form of ELVR isvalve implantation,which is toplacevalves in all the segments of an emphysematous lobe.However,valve replacements do not achieve adequate lung volume reduction in the,presence of interlobar collateral ventilation(CV).l1 in addition,with the heterogeneity existing withinthe treatment lobe,complete lobar treatment from implants may result in excessive reduction of the less diseased segments.Thus,a more targeted approach of the most severe emphysematous parts of the lobe is warranted.

关 键 词：PATIENTS lung treatment 

分 类 号：R563.3[医药卫生—呼吸系统]