Effect of Auricular Acupoint Bloodletting plus Auricular Acupressure on Sleep Quality and Neuroendocrine Level in College Students with Primary Insomnia:A Randomized Controlled Trial  

作　　者：CHEN Hao ZHANG Ming-jian WU Jia-ai SHE Yan-fen YUAN Xin-ru HUo Yun-xiang SUN Huan LIU Dao-nan SHI Xu-liang 

机构地区：[1]College of Acupuncture Moxibustion and Massage,Hebei University of Chinese Medicine,Shijiazhuang 050200,China [2]International Joint Research Center for Preponderant Diseases of Acupuncture in Hebei Province,Shijiazhuang 050200,China

出　　处：《Chinese Journal of Integrative Medicine》2022年第12期1096-1104,共9页中国结合医学杂志（英文版）

基　　金：Supported by the College Student Innovation and Entrepreneurship Training Program in Hebei Province,China(No.S201914432019S)。

摘　　要：Objective:To evaluate the effects of auricular acupoint bloodletting(AB)and auricular acupressure(AA)on sleep quality and the levels of melatonin(MT),glutamic acid(Glu),and γ-aminobutyric acid(GABA)in college students with primary insomnia,and to explore the possible mechanism.Methods:Totally 74 college students at Hebei University of Chinese Medicine with primary insomnia were selected from October 2019 to October 2020.All patients were assigned to AB+AA group(37 cases,received combination of AB and AA)and AA group(37 cases,received only AA on the same acupoints)by a random number table.Each group was treated twice a week for 4 weeks.The Pitsburgh Sleep Quality Index(PSQI)score,Chinese medicine(CM)syndrome score,total effective rate,serum concentrations of MT,Glu,and GABA,and Glu/GABA ratio were compared between the two groups after treatment and at follow-up.The safety of therapy was also evaluated.Results:After 4-week treatment,the total scores of PSQI,each PSQI component score,and the CM syndrome scores in both groups all decreased(P<0.05);the serum MT concentrations in both groups all increased(P<0.05).The concentrations of Glu and GABA in the AB+AA group were significantly higher than those in the AA group after treatment(P<0.05).However,there was no significant difference in the ratio of Glu/GABA in both groups before and after treatment(P>0.05).At follow-up,the CM syndrome score in the AB+AA group was significantly lower than that in the AA group(P<0.05).There was no significant difference between the two groups in total effective rates and adverse events(P>0.05).Conclusions:Both AB+AA and AA can relieve insomnia symptoms,but a stronger long-term effect were observed for AB+AA.AB+AA canpromote the secretion of MT,increase the levelsof Glu and GABA more effective than AA,and regulate their imbalance,and thus it may bebenificial for treating insomnia.

关 键 词：auricular acupoint bloodletting auricular acupressure INSOMNIA randomized controlled trial Chinese medicine 

分 类 号：R246.6[医药卫生—针灸推拿学]