2016-2021年山东省聊城市78例HIV抗体检测不确定者随访分析  

Follow-up analysis on 78 individuals with undetermined HIV antibody testing,Liaocheng city,Shandong province,2016 to 2021

作　　者：李倩 杨金英[1] 于海荣[2] 张春荣 李金海[4] 杜亚楠 LI Qian;YANG Jin-ying;YU Hai-rong;ZHANG Chun-rong;LI Jin-hai;DU Ya-nan(Institute of AIDS Prevention and Control,Liaocheng City Center for Disease Control and Prevention,Shandong 252000,China;Institute of Chronic Non-communicable Disease Prevention and Control,Liaocheng City Center for Disease Control and Prevention;Institute of Occupational Health,Liaocheng City Center for Disease Control and Prevention;Institute of AIDS Prevention and Control,Shandong Center for Disease Control and Prevention)

机构地区：[1]聊城市疾病预防控制中心艾滋病防制所,山东252000 [2]聊城市疾病预防控制中心慢病所 [3]聊城市疾病预防控制中心职卫所 [4]山东省疾病预防控制中心艾滋病防制所

出　　处：《预防医学论坛》2022年第11期830-833,共4页Preventive Medicine Tribune

摘　　要：目的分析2016-2021年山东省聊城市HIV抗体不确定结果者的特点及随访检测情况,为艾滋病的早发现及精准防控提供科学依据。方法收集2016-2021年山东省聊城市某艾滋病确证实验室78例首次HIV抗体确证实验结果为不确定者的资料,分析一般资料、快速试验HIV抗体检测结果、酶联免疫吸附试验S/CO值、免疫印迹法带型及2~4周后随访检测HIV抗体转归情况。结果78例首次确证不确定样本中,男性50例(64.10%),年龄20~39岁44例(56.41%),失访37例(失访率47.44%)。成功随访41例(随访率52.56%),其中26例(63.41%)随访检测阳转,男性阳转率较高、为79.31%(23/29);胶体硒快速试验和ELISA均有反应样本转阳,阳转率为88.4%(23/26);ELISA S/CO≥7的样本阳转率为95.8%(23/24)。78例首次确证不确定样本共有10种带型,主要为gp160p24(34.62%)、gp160(28.21%)、p24(20.51%)。41例随访检测中结果为3条带的阳转率最高100%(4/4),其次是2条带84.21%(16/19)。结论2016-2021年山东省聊城市某艾滋病确证实验室不确定者失访率较高;对复检试验双阳性、ELISA S/CO值较高、不确定条带多的不确定者,应尽早进行核酸检测。Objective To analyze the characteristics and follow-up testing of people with uncertain results of HIV antibody from 2016 to 2021 in Liaocheng city,Shandong province,so as to provide a scientific basis for early detection and precision prevention of AIDS.Methods The data of those whose first HIV antibody confirmatory test results were uncertain in an HIV confirmatory laboratory in Liaocheng city,Shandong province from 2016 to 2021 were collected,and the general information,the rapid test HIV antibody detection results,the enzyme-linked immunosorbent assay S/CO value,the immunoblot band type,and the follow-up detection of HIV antibody outcomes after 2-4 weeks were analyzed.Results Of 78 uncertain samples confirmed for the first time,50 were male(64.10%),44 were aged 20-39 years(56.41%),and 37(lost follow-up rate 47.44%)were lost follow-up.Positive conversion was detected at follow-up in 26(63.41%)of the 41 patients with successful follow-up(follow-up rate 52.56%),with a higher rate of 79.31%(23/29)in male.The positive rate of both colloid selenium rapid test and ELISA was 88.4%(23/26).Positive conversion rate of samples with ELISA S/CO greater than 7 was 95.8%(23/24).There were 10 bandtype in 78 unconfirmed cases,mainly gp160 p24(34.62%),gp160(28.21%)and p24(20.51%).In the follow-up test of 41 cases,the positive conversion rate of 3 bands was the highest(100%,4/4),followed by 2 bands(84.21%,16/19).Conclusion The loss to follow-up rate of uncertain individuals in a HIV confirmation laboratory was high from 2016 to 2021 in Liaocheng city,Shandong province.Nucleic acid testing should be performed as early as possible for indeterminate individuals with double-positive retest,high ELISA S/CO values,and many uncertain bands.

关 键 词：艾滋病 不确定结果 复检试验 随访检测 

分 类 号：R512.91[医药卫生—内科学] R446.6[医药卫生—临床医学]