瞬时电位香草醛受体1与炎性疼痛  

Transient potential vanillin receptor 1 and inflammatory pain

作　　者：李俊娴 李丙旭 王姣姣 马宏跃[1] 周婧[1] LI Junxian;LI Bingxu;WANG Jiaojiao;MA Hongyue;ZHOU Jing(College of Pharmacy,Nanjing University of Traditional Chinese Medicine,Nanjing 210023,China)

机构地区：[1]南京中医药大学药学院,江苏南京210023

出　　处：《沈阳药科大学学报》2022年第11期1391-1398,共8页Journal of Shenyang Pharmaceutical University

基　　金：国家自然科学基金资助项目(82073975,81673563,81102762);江苏省方剂高技术研究重点实验室/江苏省中药资源产业化过程协同创新中心资助项目(FJGJS-2015-15,ZDXM-14);江苏省青蓝工程学术带头人项目。

摘　　要：目的探究瞬时电位香草醛受体1(transient potential vanillin receptor 1,TRPV1)在炎性疼痛发生发展中的作用。方法采用Pubmed检索关键词“TRPV1”、“炎症”、“疼痛”、“激动剂”、“拮抗剂”等的相关文献,并将其进行归纳汇总。结果常见几种炎症因子激活TRPV1,参与炎性疼痛的信号传递。结论TRPV1在炎性疼痛产生的过程中发挥着至关重要的作用,通过对TRPV1进行抑制,开发基于TRPV1的受体拮抗剂,可以在一定程度上抑制炎性疼痛的产生。Objective To investigate the role of transient potential vanillin receptor 1(TRPV1)in the development of inflammatory pain.Methods Pubmed was used to search the relevant literature on keywords“TRPV1”,“inflammation”,“pain”,“agonist”,“antagonist”and so on,and summarized them.Results Several inflammatory factors activate TRPV1 and participate in the signaling of inflammatory pain.Conclusion TRPV1 plays a crucial role in the production of inflammatory pain.By inhibiting TRPV1,the development of receptor antagonists based on TRPV1 can inhibit the production of inflammatory pain to a certain extent.

关 键 词：TRPV1 炎性疼痛 作用机制 激动剂/拮抗剂 

分 类 号：R917[医药卫生—药物分析学]