基于功能磁共振成像可视化解码中医药促进脑卒中后脑功能的重塑  

Chinese medicine promotes post-stroke brain function remodeling based on visual decoding of functional magnetic resonance imaging

作　　者：张金生[1] 田力[2] 李三强[3] 张希贤 Zhang Jinsheng;Tian Li;Li Sanqiang;Zhang Xixian(The Third Affiliated Hospital of Henan University of Chinese Medicine,Zhengzhou 450000,Henan Province,China;Henan University of Chinese Medicine,Zhengzhou 450008,Henan Province,China;Medical School of Henan University of Science and Technology,Luoyang 471000,Henan Province,China)

机构地区：[1]河南中医药大学第三附属医院,河南省郑州市450000 [2]河南中医药大学,河南省郑州市450008 [3]河南科技大学医学院,河南省洛阳市471000

出　　处：《中国组织工程研究》2023年第23期3747-3754,共8页Chinese Journal of Tissue Engineering Research

基　　金：中原科技创新杰出人才项目[豫组通2020(48)号];2021年河南省重点研发与推广专项(科技攻关)(212102311134)。

摘　　要：背景:通过功能磁共振成像可视化技术直观研究大脑重塑和神经再生机制,探讨其揭示中医药促进脑功能重塑和大脑重构的可行性和科学性,提高中医临床治疗方案修订、临床疗效和预后评估的客观性。目的:利用功能磁共振成像可视化技术解码中医药促进脑卒中后大脑重塑可行性和科学性,为探讨评价中医药治疗脑卒中的临床疗效、理论创新、疗效和预后评估提供重要依据。方法:以“功能磁共振成像、磁共振弥散张量成像、局部一致性、低频振幅、中医药、脑功能重塑、神经重塑”及“diffusion tensor imaging,blood oxygenation level dependent functional magnetic resonance imaging,regional homogeneity,amplitude of low frequency fluctuation,brain remodeling,nerve regeneration,Chinese Medicine”为主题检索词,检索中国期刊全文数据库、PubMed和万方数据库的相关文献,最终纳入63篇文献进行综述。结果与结论:(1)功能磁共振成像具有无创动态特点,通过解剖、影像等多学科联合应用实时动态评估脑卒中后运动、认知及感觉等中医药治疗效果。(2)功能磁共振成像从广义上指血氧水平依赖性功能性磁共振成像、磁化转移成像及扩散张量和化学位移成像,狭义上指氧水平依赖性功能性磁共振成像。通过血氧水平依赖信号观察脑活动时血液动力学变化反映神经元活动,探讨脑能量代谢与活性的关系。(3)目前中医药如何促进脑卒中后大脑重塑和神经功能重建的研究很少,研究多停留在单指标和单靶区,缺乏全脑区的研究,如在中医药在改善脑功能障碍,促进脑功能重建和神经再生的演变全过程等方面,不能准确解读中医药科学的疗效机制,而多种疗法协同通过多靶点、多途径促进脑卒中后脑功能重塑机制目前仍为空白。(4)文章借助于功能磁共振成像可视化技术可以直观研究中医药治疗大脑重塑和神经再生的演�BACKGROUND:Through the visualization technology of functional magnetic resonance imaging(fMRI),we can intuitively study the mechanisms of brain remodeling and nerve regeneration,reveal the feasibility and scientificity of Chinese medicine that promotes brain function remodeling and brain reconstruction,and thus o bjectively improves therapeutic schedule revision,clinical efficacy and prognosis evaluation of Chinese medicine.OBJECTIVE:To decode the feasibility and scientificity of Chinese medicine that promotes post-stroke brain remodeling using fMRI visualization technologies,there by providing an important basis for exploring and evaluating the clinical efficacy,theoretical innovation,and prognosis of Chinese medicine in the treatment of stroke.METHODS:CNKI,PubMed,and WanFang were searched for relevant lite rature using diffusion tensor imaging,blood oxygenation level dependent functional magnetic resonance imaging,regional homogeneity,amplitude of low frequency fluctuation,brain remodeling,nerve regeneration,Chinese medicine as Chinese and English search terms.Finally,63 articles were selected for review.RESULTS AND CONCLUSION:fMRI has a non-invasive dynamic feature.The therapeutic efficacy of Chinese medicine on post-stroke motion,cognition and sensation can be dynamically assessed through the combination of anato my,imaging and other disciplines.fMRI,in its broad sense,refers to blood oxygen level dependent fMRI,magnetization transfer imaging,diffusion tensor and chemical shift imaging,while its narrow concept only indicates oxygen level dependent fMRI.This imaging technology is to explore the relationship between brain energy metabolism and activity by observing the hemodynamic changes during brain activity and reflecting the neuronal activity based on the blood oxygen level dependent signals.At present,there are few studies on how Chinese medicine promotes brain remodeling and nerve function reconstruction after stroke.Relevant research mostly focuses on single index and single target area and there is a la

关 键 词：功能磁共振成像 可视化 微环境 中医药 脑功能重塑 扩散张量成像 局部一致性分析 低频振幅 

分 类 号：R452[医药卫生—治疗学] R363[医药卫生—临床医学] R364