真菌苦马豆素合成途径中SWN基因簇的研究进展  

Research Progress of SWN Gene Cluster in the Synthetic Pathway of Swainsonine

作　　者：凯乐 卢萍[1] 姜凯 李玉玲[1] KAI Le(College of Life Science and Technology,Inner Mongolia Normal University,Hohhot,Inner Mongolia 010022)

机构地区：[1]内蒙古师范大学生命科学与技术学院,内蒙古呼和浩特010022

出　　处：《农业灾害研究》2022年第11期152-154,共3页Journal of Agricultural Catastrophology

基　　金：国家自然科学基金(31960130、30860049);内蒙古自然科学基金(2022MS03014);内蒙古师范大学研究生科研创新基金(CXJJS21146)。

摘　　要：苦马豆素(Swainsonine,SW)是有毒的吲哚里西啶类生物碱,牲畜采食含SW的疯草植物会导致中毒,造成畜牧业的经济损失。SW还具有抗肿瘤和免疫增强作用,化学合成SW成本较高。有学者发现,产SW的真菌含SWN基因簇,在SW生物合成通路中起重要作用。对SWN基因簇的基因成分和基因功能进行综述,旨在为明晰SW合成的分子机制和代谢途径提供参考,为控制疯草蔓延、促进草原畜牧业发展提供理论支持。Swainsonine(SW)is a toxic indolizidine alkaloid.Livestock eating forage containing SW will lead to poisoning,resulting in economic losses of animal husbandry.SW also has antitumor and immunity enhancing effects,and the cost of chemical synthesis of SW is high.Some scholars have found that SW-producing fungi contain SWN cluster,suggesting that plays an important role in the biosynthesis pathway of SW.This paper reviews the gene composition and gene function of SWN,aiming at providing reference for clarifying the molecular mechanism and metabolic pathway of SW synthesis,and also providing theoretical support for controlling the spread of crazy grass and promoting the development of grassland animal husbandry.

关 键 词：苦马豆素 SWN基因簇 基因功能 

分 类 号：Q786[生物学—分子生物学]