自拟祛痰化瘀汤治疗多囊卵巢综合征合并冠状动脉微循环障碍的效果观察  

Effect of self-made Qutan Huayu decoction on the treatment of polycystic ovary syndrome complicated with coronary microvascular dysfunction

作　　者：邵昱玮 蒋姗姗 王亚静 庞俏燕 Shao Yuwei;Jiang Shanshan;Wang Yajing;Pang Qiaoyan(Basic Medicine College,Guangxi University of Chinese Medicine,Nanning 530000,China;Department of Gynecology,Ruikang Hospital Affiliated to Guangxi University of Chinese Medicine,Nanning 530011,China)

机构地区：[1]广西中医药大学基础医学院,南宁530000 [2]广西中医药大学附属瑞康医院妇科,南宁530011

出　　处：《中国医药》2022年第12期1864-1868,共5页China Medicine

基　　金：广西壮族自治区自然科学基金(2020GXNSFAA297164)。

摘　　要：目的观察自拟祛痰化瘀汤治疗多囊卵巢综合征(PCOS)合并冠状动脉微循环障碍(CMVD)的效果。方法选取广西中医药大学附属瑞康医院2018年6月至2021年6月收治的PCOS合并CMVD患者84例,根据随机数字表法分为对照组和观察组,各42例。对照组给予常规心血管药物及调经治疗;观察组在对照组基础上给予自拟祛痰化瘀汤治疗。比较2组治疗前后中医证候评分、血脂、性激素、血管内皮功能指标水平、微循环阻力指数(IMR)及冠状动脉血流储备分数(FFR)。结果治疗后,2组中医证候评分均低于治疗前,且观察组均低于对照组(均P<0.05)。2组三酰甘油、总胆固醇、低密度脂蛋白胆固醇水平均低于治疗前,且观察组均低于对照组,高密度脂蛋白胆固醇水平均高于治疗前,且观察组高于对照组(均P<0.05)。2组血清卵泡刺激素、黄体生成素、睾酮水平均低于治疗前,且观察组均低于对照组[(5.1±0.9)U/L比(6.2±1.0)U/L、(5.2±1.3)U/L比(7.9±2.9)U/L、(0.26±0.04)μg/L比(0.41±0.16)μg/L],雌二醇、抗米勒管激素水平均高于治疗前,且观察组均高于对照组[(113±30)ng/L比(99±24)ng/L、(5.5±1.3)μg/L比(3.9±1.0)μg/L](均P<0.05)。2组血清血管紧张素Ⅱ、内皮素1水平均低于治疗前,且观察组均低于对照组,一氧化氮水平均高于治疗前,且观察组高于对照组(均P<0.05)。2组IMR均低于治疗前,且观察组低于对照组,2组FFR均高于治疗前,且观察组高于对照组(均P<0.05)。观察组总有效率高于对照组(P=0.024)。结论自拟祛痰化瘀汤可降低PCOS合并CMVD患者血脂水平,改善性激素水平、血管内皮功能及微血管功能,临床疗效显著。Objective To observe the effect of self-made Qutan Huayu decoction on the treatment of polycystic ovary syndrome(PCOS)complicated with coronary microvascular dysfunction(CMVD).Methods A total of 84 patients with PCOS and CMVD admitted to Ruikang Hospital Affiliated to Guangxi University of Chinese Medicine from June 2018 to June 2021 were enrolled.Patients were randomly divided into control group and observation group,with 42 cases in each group.The control group received conventional cardiovascular drugs and menstrual regulation treatment.The observation group was treated with self-made Qutan Huayu decoction on the basis of the control group.The scores of traditional Chinese medicine syndromes,serum lipid,sex hormone,vascular endothelial function indexes,microcirculation resistance index(IMR)and coronary fractional flow reserve(FFR)were compared between the two groups before and after treatment.Results After treatment,scores of traditional Chinese medicine syndromes in both groups were lower than those before treatment,and the scores in the observation group were lower than those in the control group(all P<0.05).Levels of triacylglycerol,total cholesterol,low-density lipoprotein cholesterol in both groups were lower than those before treatment,and the levels in the observation group were lower than those in the control group;levels of high-density lipoprotein cholesterol in both groups were higher than those before treatment,and the level in the observation group was higher than that in the control group(all P<0.05).Levels of follicle stimulating hormone,luteinizing hormone and testosterone in both groups were lower than those before treatment,and the levels in the observation group were lower than those in the control group[(5.1±0.9)U/L vs(6.2±1.0)U/L,(5.2±1.3)U/L vs(7.9±2.9)U/L,(0.26±0.04)μg/L vs(0.41±0.16)μg/L];levels of estradiol and anti-Müllerian hormone in both groups were higher than those before treatment and the levels in the observation group were higher than those in the control group[(113±

关 键 词：多囊卵巢综合征 冠状动脉微循环障碍 祛痰化瘀汤 

分 类 号：R711.5[医药卫生—妇产科学]