芳香化酶抑制剂预防绝经后子宫内膜息肉复发的临床疗效分析  

Analysis on the clinical efficacy of aromatase inhibitor in preventing relapse of postmenopausal endometrial polyps

作　　者：金欣[1] 李桂林[1] JIN Xin;LI Guilin(Ward XV,Department of Gynecology,Xuzhou Maternity and Child Health Care Hospital,Jiangsu,Xuzhou 221009,China)

机构地区：[1]江苏省徐州市妇幼保健院妇科十五病区,江苏徐州221009

出　　处：《中国医药科学》2022年第23期116-119,共4页China Medicine And Pharmacy

摘　　要：目的 探讨芳香化酶抑制剂(AI)在预防绝经后子宫内膜息肉复发的临床价值及意义。方法 选取2019年1月至2021年1月徐州市妇幼保健院临床确诊为子宫内膜息肉的绝经后患者58例,均行宫腔镜下子宫内膜息肉切除术(TCRP)。根据随机数表法将患者分为研究组(n=30)和对照组(n=28),研究组应用芳香化酶抑制剂,对照组术后仅观察随访。随访观察患者术后生化指标、体重指数(BMI)、子宫内膜厚度、外周血中雌激素水平、息肉复发情况等。结果 两组患者术后生化指标和BMI比较,差异无统计学意义(P> 0.05)。两组子宫内膜厚度、外周血中雌激素水平比较,差异有统计学意义(P <0.05)。研究组无术后复发,对照组2例复发,差异有统计学意义(P <0.05)。结论 AI在预防绝经后患者子宫内膜息肉复发具有一定的临床疗效和意义,期待进一步探索后临床应用推广。Objective To investigate the clinical value and significance of aromatase inhibitor(AI) in preventing relapse of postmenopausal endometrial polyps. Methods A total of 58 postmenopausal patients with clinically diagnosed endometrial polyps admitted to Xuzhou Maternity and Child Health Care Hospital from January 2019to January 2021 were selected, all of whom underwent transcervical resection of polyps(TCRP). They were divided into the study group(n=30) and the control group(n=28) according to the random number table method.The study group was treated with AI, while the control group was only observed and followed up after operation.The patients’ postoperative biochemical indices, body mass index(BMI), endometrial thickness, estrogen level in peripheral blood and polyp relapse were observed and followed up. Results There were no statistically significant differences in postoperative biochemical indices and BMI between the two groups of patients(P > 0.05). There were statistically significant differences in endometrial thickness and estrogen level in peripheral blood between the two groups of patients(P < 0.05). There was no postoperative relapse in the study group, and there were 2 cases of relapse in the control group, with statistically significant differences between the two groups(P < 0.05). Conclusion AI has certain clinical efficacy and significance in preventing the relapse of endometrial polyps in postmenopausal patients.Therefore, clinical application and promotion after further exploration are looked forward to.

关 键 词：芳香化酶抑制剂 绝经后子宫内膜息肉 宫腔镜下子宫内膜息肉切除术 复发 

分 类 号：R711.74[医药卫生—妇产科学]