血清MIF、G-CSF水平对早产儿支气管肺发育不良的诊断价值  

Diagnostic value of serum MIF and G-CSF levels for bronchopulmonary dysplasia of premature infants

作　　者：王晶磊 姬建刚 张勇华 靳丽娜 毕艳旭 WANG Jinglei;JI Jian'gang;ZHANG Yonghua;JIN Lina;BI Yanxu(Department of Neonatology,Linfen Central Hospital,Linfen 041000,China)

机构地区：[1]临汾市中心医院新生儿科,山西临汾041000

出　　处：《山东医药》2023年第1期24-27,共4页Shandong Medical Journal

基　　金：中华国际科学交流基金会检验检测科技专项基金(Z2022LSXB003)。

摘　　要：目的探讨血清巨噬细胞移动抑制因子(MIF)、粒细胞集落刺激因子(G-CSF)水平对早产儿支气管肺发育不良(BPD)的诊断价值。方法选择早产儿126例,其中发生BPD 35例(BPD组)、未发生BPD 91例(非BPD组)。采集两组外周静脉血,离心留取血清,采用ELISA法检测血清MIF、G-CSF。比较两组胎龄、出生体质量、性别、胎儿宫内生长受限、新生儿窒息、呼吸窘迫、机械通气、氧疗时间、使用肺表面活性剂以及其母亲年龄、分娩方式、孕期吸烟、胎膜早破、宫内感染、妊娠合并症等临床资料,将有统计学差异的指标纳入多因素Logistic回归模型,分析早产儿BPD的危险因素。采用受试者工作特征(ROC)曲线分析血清MIF、G-CSF水平对早产儿BPD的诊断价值。结果BPD组血清MIF、G-CSF水平均显著高于非BPD组(P均<0.05)。单因素分析显示,两组胎龄、出生体质量、胎儿宫内生长受限、新生儿窒息、呼吸窘迫、机械通气、氧疗时间、使用肺表面活性剂以及母亲孕期吸烟比例比较差异均有统计学意义(P均<0.05),而性别、分娩方式、母亲年龄及妊娠期合并高血压、糖尿病和胎膜早破、宫内感染比例比较差异均无统计学意义(P均>0.05)。多因素Logistic回归分析显示,氧疗时间长及血清MIF、G-CSF水平升高是早产儿BPD的独立危险因素,而胎龄大则为其独立保护因素(P均<0.05)。ROC曲线分析显示,血清MIF、G-CSF水平单独和联合诊断早产儿BPD的曲线下面积(AUC)分别为0.743、0.684、0.930,血清MIF、G-CSF水平联合诊断早产儿BPD的AUC显著高于血清MIF、G-CSF水平单独(P均<0.05)。结论血清MIF、G-CSF水平与早产儿BPD密切相关;血清MIF、G-CSF水平对早产儿BPD均有一定诊断价值,二者联合诊断价值更高。Objective To investigate the diagnostic value of serum macrophage migration inhibitory factor(MIF)and granulocyte-colony stimulating factor(G-CSF)levels for bronchopulmonary dysplasia(BPD)of premature infants.Methods A total of 126 preterm infants were selected,including 35 cases with BPD(BPD group)and 91 cases without BPD(non-BPD group).The peripheral venous blood of the two groups was collected,the serum was centrifuged,and the serum MIF and G-CSF were detected by ELISA.The gestational age,birth weight,gender,fetal intrauterine growth restriction,neonatal asphyxia,respiratory distress,mechanical ventilation,oxygen therapy time,use of pulmonary surfactant,maternal age,delivery mode,smoking during pregnancy,premature rupture of membranes,intrauterine infection,pregnancy complications and other clinical data were compared between the two groups.The indicators with statistical differences were included in the multivariate Logistic regression model to analyze the risk factors of BPD in premature infants.Receiver operating characteristic(ROC)curve was used to analyze the predictive value of serum MIF and G-CSF levels for BPD in preterm infants.Results The serum levels of MIF and G-CSF in the BPD group were significantly higher than those in the non-BPD group(all P<0.05).Univariate analysis showed that there were significant differences in gestational age,birth weight,fetal intrauterine growth restriction,neonatal asphyxia,respiratory distress,mechanical ventilation,oxygen therapy time,use of pulmonary surfactant and smoking during pregnancy between the two groups(all P<0.05),while there were no significant differences in gender,delivery mode,maternal age,the proportions of pregnancy complicated with hypertension,diabetes,premature rupture of membranes,or intrauterine infection(all P>0.05).Multivariate Logistic regression analysis showed that prolonged oxygen therapy and increased serum MIF and G-CSF levels were independent risk factors for BPD in preterm infants,while older gestational age was an independent protecti

关 键 词：支气管肺发育不良 早产儿 巨噬细胞移动抑制因子 粒细胞集落刺激因子 

分 类 号：R725.6[医药卫生—儿科]