卵巢储备功能减退的多因素分析  

Multivariate analysis of diminished ovarian reserve

作　　者：呼蕾 谢云 邱瑞萍 石喜习 张雷 王林 Hu Lei;Xie Yun;Qiu Ruiping;Shi Xixi;Zhang Lei;Wang Lin(Department of Clinical Labrotory,Northwest Women′s and Children′s Hospital,Shaanxi 710061,China)

机构地区：[1]西北妇女儿童医院医学检验中心,西安710061 [2]西北妇女儿童医院医学遗传中心,西安710061

出　　处：《山西医药杂志》2022年第20期2287-2291,共5页Shanxi Medical Journal

基　　金：陕西省自然科学基础研究计划项目(2016JQ8058);西北妇女儿童医院院内科研项目(2020LQ04)。

摘　　要：目的探讨卵巢储备功能减退(DOR)与体质指数(BMI)、减肥史、生产史、生活方式等因素的关系,为DOR的预防和临床治疗提供理论依据。方法以2019年6月至2020年6月在西北妇女儿童医院就诊,年龄<40岁诊断为DOR的女性71例作为研究对象,研究BMI、减肥史、生产史、生活方式等因素与DOR的相关性。结果BMI<18.5 kg/m^(2)的女性发生DOR的风险是BMI正常女性的4.384倍(P<0.05);过度减肥史(≤6个月和>6个月)的女性发生DOR的风险分别是无不良减肥史女性的2.930及5.505倍(P<0.05)。每周中等强度运动量>4 h的女性发生DOR的风险是每周中等强度运动量2~4 h女性的3.880倍(P<0.05)。流产史≥2次的女性发生DOR的风险是无流产史女性的2.946倍(P<0.05)。补充维生素D<3个月的女性发生DOR的风险是补充维生素D>6个月女性的5.900倍(P<0.05)。结论BMI<18.5 kg/m2,不良减肥史,中等强度以上运动量>4 h/周,≥2次的流产史,维生素D补充<3个月均为卵巢储备功能减退的危险因素。育龄期女性应当提高生殖保健的意识,保持正常BMI,养成健康的生活习惯,预防DOR的发生。Objective To explore the relationship between the diminished ovarian reserve(DOR)and body mass index(BMI),loss weight time,the number of childbirth,lifestyle,etc.,and provide references for prevention and clinical treatment of DOR.Methods Seventy-one DOR women under 40 years old in Northwest Women′s and Children′s Hospital from June 2019 to June 2020 were selected to study the correlation between BMI,weight loss history,production history,lifestyle and DOR.Results The risk of DOR in women with BMI<18.5 kg/m^(2) was 4.384 times higher than that of the normal BMI women(P<0.05).Women with a history of over dieting for≤6 months and>6 months were 2.930 and 5.505 times more likely to have DOR than those without a history of adverse weight loss(P<0.05).The risk of DOR in women who exercised more than 4 hours per week was 3.880 times than that in women who exercised more than 2~4 hours per week(P<0.05).The risk of DOR in women with 2 or more abortions was 2.946 times higher than that in women without abortions(P<0.05).Women with vitamin less than 3 months were 5.900 times more likely to have DOR than those with vitamin D more than 6 months(P<0.05).Conclusion BMI<18.5 kg/m2,poor weight loss history,excessive exercise(4 h/week),2 or more abortions history,and<3 mouths vitamin D supplement are all risk factors of ovarian reserve dysfunction.Women of childbearing age should improve their awareness of reproductive health care,maintain a normal BMI,develop healthy living habits,and prevent the occurrence of DOR.

关 键 词：卵巢功能试验 卵巢功能减退 生活方式 多因素分析 

分 类 号：R711.75[医药卫生—妇产科学]