河南省围产儿先天性心脏病发病率及影响因素分析  

Analysis of incidence and influencing factors of congenital heart disease in perinatal infants in Henan province

作　　者：杜真 张猛 赵冰[1] 常慧 胡孟彩[1] 梁肖 王美芝 DU Zhen;ZHANG Meng;ZHAO Bing;CHANG Hui;HU Mengcai;LIANG Xiao;WANG Meizhi(Department of Obstetrics and Gynecology,the Third Affiliated Hospital of Zhengzhou University,Zhengzhou 450052,Henan Province,China)

机构地区：[1]郑州大学第三附属医院妇产科,河南郑州450052

出　　处：《新乡医学院学报》2023年第1期45-49,共5页Journal of Xinxiang Medical University

基　　金：河南省科技厅重点研发与推广专项(科技攻关)(编号:222102310418)。

摘　　要：目的分析河南省围产儿先天性心脏病(CHD)发生情况、变化趋势及影响因素。方法选择2011~2020年河南省37家国家级出生缺陷监测点统计的孕满28周出生至产后7d的围产儿1356838名为研究对象,比较不同地区、胎儿性别、产妇年龄的围产儿CHD发病率。建立Joinpiont回归模型分析2011~2020年河南省围产儿CHD发病率的时间变化趋势,以年度变化百分比(APC)表示各分段区间内部趋势,平均年度变化百分比(AAPC)表示整体变化趋势;采用Joinpiont平行性检验比较不同地区、母亲年龄及围产儿性别CHD发病率差距的趋势。结果2011~2020年河南省共检出CHD围产儿19004例,总发病率为140.06/万,围产儿CHD发病率呈逐年上升趋势(AAPC=43.3%,P<0.05)。2011~2020年河南省城镇围产儿的CHD发病率显著高于农村,男婴围产儿CHD发病率显著高于女婴围产儿,高龄产妇的围产儿CHD发病率显著高于低龄产妇(χ2=7259.160、5415.473、499.520,P<0.05)。2011~2020年河南省城镇、农村地区围产儿CHD发病率均呈逐年上升趋势(AAPC=42.5%、44.5%,P<0.05);城镇与农村地区围产儿CHD发病率差距呈逐年上升趋势(P<0.05)。2011~2020年河南省男婴和女婴CHD发病率均呈逐年上升趋势(AAPC=44.3%、42.7%,P<0.05)。2011~2020年河南省非高龄、高龄孕产妇的围产儿CHD发病率均呈逐年上升趋势(AAPC=42.9%、42.7%,P<0.05);高龄与非高龄孕产妇的围产儿CHD发病率差距呈逐年上升趋势(P<0.05)。结论2011~2020年河南省围产儿CHD的发病率呈上升趋势,且地区分布、胎儿性别、产妇年龄与围产儿CHD发生率有关。Objective To analyze the incidence,trend and influencing factors of congenital heart disease(CHD)in perinatal infants in Henan province.Methods From 2011 to 2020,1356838 perinatal infants born from 28 weeks of pregnancy to 7 days after delivery were selected from 37 national birth defect monitoring points in Henan province as the research subjects,and the incidence of CHD in perinatal infants from different regions,fetal sex and maternal age were compared.The Joinpiont regression model was established to analyze the temporal change trend of the incidence rate of CHD in perinatal infants in Henan province from 2011 to 2010;the annual percentage change(APC)represented the internal trend of each segment,and the average annual percentage change(AAPC)represented the overall change trend.The trend of gap in incidence rate of CHD in different regions,mother′s age and perinatal sex was compared by the Joinpiont parallel test.Results From 2011 to 2020,19004 cases of perinatal infants with CHD were detected in Henan province,with a total incidence of 140.06/10000;the incidence of CHD in perinatal infants showed an increasing trend year by year(AAPC=43.3%,P<0.05).From 2011 to 2020,the incidence of CHD in urban perinatal infants in Henan province was significantly higher than that in rural areas,the incidence of CHD in male perinatal infants was significantly higher than that in female perinatal infants,and the incidence of CHD in perinatal infants in older mothers was significantly higher than that in younger mothers(χ^(2)=7259.160,5415.473,499.520;P<0.05).From 2011 to 2020,the incidence of CHD in perinatal infants in urban and rural areas of Henan province showed an increasing trend year by year(AAPC=42.5%,44.5%;P<0.05);the difference between urban and rural areas in the incidence of CHD in perinatal infants was increasing year by year(P<0.05).From 2011 to 2020,the incidence of CHD in male perinatal and famale perinatal infants in Henan province showed an increasing trend year by year(AAPC=44.3%,42.7%;P<0.05).From 2011

关 键 词：先天性心脏病 Joinpoint回归 影响因素 

分 类 号：R541.1[医药卫生—心血管疾病]