胎儿娩出即刻注射卡前列素氨丁三醇防治宫缩乏力性产妇产后出血的效果  

Effects of immediate injection of Carprostol tromethamine at delivery of the fetus in prevention of postpartum hemorrhage due to uterine inertia

作　　者：岳洋 YUE Yang(Department of Obstetrics and Gynecology of Dalian Liaoyu Hospital,Dalian 116113 Liaoning,China)

机构地区：[1]大连辽渔医院妇产科,辽宁大连116113

出　　处：《中国民康医学》2022年第23期56-58,共3页Medical Journal of Chinese People’s Health

摘　　要：目的:观察胎儿娩出即刻注射卡前列素氨丁三醇防治宫缩乏力性产妇产后出血的效果。方法:选取2020年4月至2021年4月于该院行剖宫产的68例产妇进行前瞻性研究,按照随机数字表法分为即刻组与出血组各34例。两组均常规应用缩宫素注射液预防产后出血,在此基础上,即刻组在胎儿娩出即刻于宫体注射卡前列素氨丁三醇,出血组在产妇出血量>300 mL时于宫体注射卡前列素氨丁三醇,比较两组术中、产后2 h、产后24 h出血量,产后出血发生率,血红蛋白水平和凝血功能指标(血小板计数、纤维蛋白原、D-二聚体)水平。结果:即刻组产后2 h、产后24 h出血量均低于出血组,差异有统计学意义(P<0.05);即刻组产后出血发生率为5.88%,明显低于出血组的23.53%,差异有统计学意义(P<0.05);产后24 h,即刻组血红蛋白水平、血小板计数均高于出血组,纤维蛋白原水平低于出血组,差异有统计学意义(P<0.05);两组术中出血量、产后24 h D-二聚体水平比较,差异无统计学意义(P>0.05)。结论:胎儿娩出即刻注射卡前列素氨丁三醇应用于防治宫缩乏力性产妇产后出血可降低产后出血量和产后出血发生率,改善凝血功能指标水平,以及提高血红蛋白水平,效果优于产妇出血量>300 mL时注射卡前列素氨丁三醇。Objective:To observe effects of immediate injection of Carprostol tromethamine at delivery of the fetus in prevention of postpartum hemorrhage due to uterine inertia.Methods:A prospective study was conducted on 68 parturients who underwent cesarean section in the hospital from April 2020 to April 2021.They were divided into immediate group and hemorrhage group according to the random number table method,34 cases in each group.Both groups were routinely treated with Oxytocin injection to prevent postpartum hemorrhage.On this basis,the immediate group was given the immediate injection of Carprostol tromethamine at delivery of the fetus,while the hemorrhage group was injected with Carprostol tromethamine into the body of uterus when the amount of maternal bleeding was>300 mL.The amount of bleeding during the surgery as well as 2 h and 24 h after delivery,the incidence of postpartum hemorrhage,the hemoglobin level,and the coagulation function index levels(platelet count,fibrinogen and D-dimer)were compared between the two groups.Results:The amounts of bleeding 2 h and 24 h after delivery in the immediate group were lower than those in the hemorrhage group,and the differences were statistically significant(P<0.05).The incidence of postpartum hemorrhage in the immediate group was 5.88%,which was significantly lower than 23.53%in the hemorrhage group,and the difference was statistically significant(P<0.05).24h after the delivery,the hemoglobin level and the platelet count in the immediate group were higher than those in the hemorrhage group,the fibrinogen level was lower than that in the hemorrhage group,and the differences were statistically significant(P<0.05).However,there were no significant differences in the intraoperative blood loss and the 24 h postpartum D-dimer level between the two groups(P>0.05).Conclusions:Immediate injection of Carprostol tromethamine at delivery of the fetus in prevention of postpartum hemorrhage due to uterine inertia can reduce the amount of postpartum hemorrhage and the incidence of po

关 键 词：宫缩乏力 产后出血 剖宫产 卡前列素氨丁三醇 血红蛋白 纤维蛋白原 D-二聚体 

分 类 号：R714.461[医药卫生—妇产科学]