丙种球蛋白联合糖皮质激素治疗过敏性紫癜肾炎患儿的效果  

Effects of gamma globulin combined with glucocorticoids in treatment of children with Henoch-Schonlein purpura nephritis

作　　者：聂上清 NIE Shangqing(2^(nd) Department of Pediatrics of Guangshan County People’s Hospital,Xinyang 465400 Henan,China)

机构地区：[1]光山县人民医院儿二科,河南信阳465400

出　　处：《中国民康医学》2022年第23期59-62,共4页Medical Journal of Chinese People’s Health

摘　　要：目的:观察丙种球蛋白联合糖皮质激素治疗过敏性紫癜肾炎患儿的效果。方法:选取2016年3月至2020年12月该院收治的82例过敏性紫癜肾炎患儿进行前瞻性研究,按照随机数字表法将其分为对照组与观察组各41例。对照组采用糖皮质激素治疗,观察组在对照组基础上联合丙种球蛋白治疗,比较两组临床疗效、治疗前后24 h尿蛋白、24 h尿红细胞、炎性因子[白细胞介素-1β(IL-1β)、肿瘤坏死因子-α(TNF-α)]水平、免疫功能指标[免疫球蛋白A(IgA)、免疫球蛋白M(IgM)、免疫球蛋白G(IgG)]水平和不良反应发生率。结果:观察组治疗总有效率为92.68%(38/41),高于对照组的73.17%(30/41),差异有统计学意义(P<0.05);治疗后,两组24 h尿蛋白水平、24 h尿红细胞计数均低于治疗前,且观察组低于对照组,差异有统计学意义(P<0.05);治疗后,两组IL-1β、TNF-α水平均低于治疗前,且观察组低于对照组,差异有统计学意义(P<0.05);两组IgA、IgM、IgG水平均低于治疗前,且观察组低于对照组,差异有统计学意义(P<0.05);两组不良反应发生率比较,差异无统计学意义(P>0.05)。结论:丙种球蛋白联合糖皮质激素治疗过敏性紫癜肾炎患儿可提高治疗总有效率,降低24 h尿蛋白水平、24 h尿红细胞计数、炎性因子水平和免疫功能指标水平,其效果优于单纯糖皮质激素治疗。Objective:To observe effects of gamma globulin combined with glucocorticoids in treatment of children with Henoch-Schonlein purpura nephritis.Methods:A prospective study was conducted on 82 children with Henoch-Schonlein purpura nephritis admitted to the hospital from March 2016 to December 2020.They were divided into control group and observation group according to the random number table method,41 cases in each group.The control group was treated with glucocorticoids,while the observation group was treated with gamma globulin on the basis of that of the control group.The clinical efficacy,the levels of 24 h urine protein and 24 h red blood cells in urine,the inflammatory factor levels[interleukin-1β(IL-1β),tumor necrosis factor-α(TNF-α)],the immune function index levels[immunoglobulin A(IgA),immunoglobulin M(IgM),immunoglobulin G(IgG)],and the incidence of adverse reactions were compared between the two groups.Results:The total effective rate of treatment in the observation group was 92.68%(38/41),which was higher than 73.17%(30/41)in the control group,and the difference was statistically significant(P<0.05).After the treatment,the levels of 24 h urine protein and 24 h red blood cell count in urine in the two groups were lower than those before the treatment,those in the observation group were lower than those in the control group,and the differences were statistically significant(P<0.05).After the treatment,the levels of IL-1βand TNF-αin the two groups were lower than those before the treatment,those of the observation group were lower than those of the control group,and the differences were statistically significant(P<0.05).The levels of IgA,IgM and IgG in the two groups were lower than those before the treatment,those of the observation group were lower than those of the control group,and the differences were statistically significant(P<0.05).However,there was no significant difference in the incidence of adverse reactions between the two groups(P>0.05).Conclusions:Gamma globulin combined with glucocor

关 键 词：小儿过敏性紫癜肾炎 丙种球蛋白 糖皮质激素 炎性因子 免疫功能 不良反应 

分 类 号：R725[医药卫生—儿科]