干扰素联合双歧杆菌四联活菌治疗轮状病毒性胃肠炎患儿的效果  

Effects of Interferon combined with Viable bifidobacterium quadruple in treatment of children with rotavirus gastroenteritis

作　　者：宋坤蔚 马应祥 SONG Kunwei;MA Yingxiang(Children’s Hospital Affiliated to Zhengzhou University,Henan Children’s Hospital,Zhengzhou Children’s Hospital,Zhengzhou 450000 Henan,China)

机构地区：[1]郑州大学附属儿童医院河南省儿童医院郑州儿童医院,河南郑州450000

出　　处：《中国民康医学》2022年第23期63-65,75,共4页Medical Journal of Chinese People’s Health

摘　　要：目的:观察干扰素联合双歧杆菌四联活菌治疗轮状病毒性胃肠炎患儿的效果。方法:选取2020年6月至2021年6月该院收治的134例轮状病毒性胃肠炎患儿进行前瞻性研究,按照随机数字表法分为对照组和观察组各67例。对照组给予双歧杆菌四联活菌片治疗,观察组在对照组基础上联合干扰素治疗,比较两组临床疗效,临床症状消失时间,治疗前后胃肠激素指标[胃动素(MOT)、胃泌素(GAS)、血管活性肠肽(VIP)]水平、炎性因子[白细胞介素(IL)-6、IL-7,C反应蛋白(CRP)]水平,以及不良反应发生率。结果:观察组治疗总有效率为95.52%,高于对照组的79.10%,差异有统计学意义(P<0.05);观察组退热时间、止呕时间、止痛时间、止泻时间等临床症状消失时间均短于对照组,差异有统计学意义(P<0.05);治疗后,观察组MOT、GAS、VIP水平均低于对照组,差异有统计学意义(P<0.05);观察组IL-6、IL-7、CRP等炎性因子水平均低于对照组,差异有统计学意义(P<0.05);两组均未发生明显不良反应。结论:干扰素联合双歧杆菌四联活菌治疗轮状病毒性胃肠炎患儿可提高临床疗效,缩短临床症状消失时间,降低胃肠激素指标和炎性因子水平,其效果优于单纯双歧杆菌四联活菌治疗。Objective:To observe the effects of Interferon combined with Viable bifidobacterium quadruple in treatment of children with rotavirus gastroenteritis.Methods:A prospective study was conducted on 134 children with rotavirus gastroenteritis admitted to this hospital from June 2020 to June 2021.They were divided into control group and observation group according to the random number table method,67 cases in each.The control group was treated with Viable bifidobacterium quadruple tablets,while the observation group was treated with Interferon on the basis of that of the control group.The clinical efficacy,the disappearance time of clinical symptoms,the gastrointestinal hormone index levels[motilin(MOT),gastrin(GAS),vasoactive intestinal peptide(VIP)]before and after the treatment,the inflammatory factor levels[interleukin(IL)-6,IL-7,C-reactive protein(CRP)],and the incidence of adverse reactions were compared between the two groups.Results:The total effective rate of treatment in the observation group was 95.52%,which was higher than 79.10%in the control group,and the difference was statistically significant(P<0.05).The disappearance time of clinical symptoms such as antipyretic time,antiemetic time,analgesic time and antidiarrheal time in the observation group were shorter than those in the control group,and the differences were statistically significant(P<0.05).After the treatment,the levels of MOT,GAS and VIP in the observation group were lower than those in the control group,and the differences were statistically significant(P<0.05).The levels of IL-6,IL-7,CRP and other inflammatory factors in the observation group were lower than those in the control group,and the differences were statistically significant(P<0.05).No obvious adverse reactions occurred in both groups.Conclusions:Interferon combined with Viable bifidobacterium quadruple can improve clinical efficacy,shorten the disappearance time of clinical symptoms,and reduce the levels of gastrointestinal hormones and inflammatory factors.Moreover,it is superio

关 键 词：干扰素 双歧杆菌四联活菌 轮状病毒 胃肠炎 胃肠激素 炎性因子 

分 类 号：R687.3[医药卫生—骨科学]