胆固醇/三酰甘油水平升高对痛风发病频率的影响  

Effect of elevated cholesterol and triglyceride levels on frequency of gout attacks

作　　者：朱子文 李琳 李晓玲 马艳 项楠 张敏 陶金辉 ZHU Zi-wen;LI Lin;LI Xiao-ling;MA Yan;XIANG Nan;ZHANG Min;TAO Jin-hui(Department of Rheumatology and Immunology,Anhui Provincial Hospital Affiliated to Anhui Medical University,Hefei Anhui 230001,China)

机构地区：[1]安徽医科大学附属省立医院风湿免疫科,安徽合肥230001

出　　处：《蚌埠医学院学报》2022年第12期1639-1642,1646,共5页Journal of Bengbu Medical College

基　　金：国家自然科学基金项目(81771774);安徽省重点研究与开发计划(201904a07020103)。

摘　　要：目的:探讨血脂水平升高对痛风发病频率的影响。方法:选取痛风病人158例,根据血脂水平分为胆固醇和三酰甘油均正常组(A组)56例、单纯胆固醇升高组(B组)21例、单纯三酰甘油升高组(C组)50例及胆固醇和三酰甘油均升高组(D组)31例。采用队列研究比较不同血脂水平病人痛风发病频率。结果:与A组比较,B组、C组、D组1个月、3个月、6个月及12个月内痛风发病频率均增加(P<0.05);随着时间的延长,4组不同时间段痛风发病频率增加(P<0.05)。按年龄、体质量指数、病程、尿酸和血糖水平进行配对,结果显示,A组与B组共配对14对,记为A1组、B1组,B1组3、6、12个月痛风发病频率均明显高于A1组(P<0.01);A组与C组共配对28对,记为A2组、C2组,C2组3、6、12个月痛风发病频率均高于A2组(P<0.05~P<0.01);A组与D组共配对13对,记为A3、D3组,D3组3、6、12个月痛风发病频率均明显高于A3组(P<0.01)。结论:血脂水平升高可以增加痛风发病频率。Objective:To investigate the effect of elevated blood lipid levels on the frequency of gout attacks.Methods:A total of 158 gout patients were selected and divided into normal cholesterol and triglyceride group(group A,n=56),simple elevated cholesterol group(group B,n=21),simple elevated triglyceride group(group C,n=50)and elevated cholesterol and triglyceride group(group D,n=31)according to the blood lipid levels.A cohort study was conducted to compare the frequency of gout attacks in patients with different blood lipid levels.Results:Compared with the group A,the frequency of gout attacks in the group B,group C and group D increased at 1,3,6 and 12 months(P<0.05),and with the extension of time,the frequency of gout attacks in the four groups increased at different time periods(P<0.05).The patients were paired according to age,body mass index,course of disease,uric acid and blood glucose level,and the results showed that group A and group B were paired with 14 pairs,which were recorded as group A1 and group B1,the frequency of gout attacks in the group B1 was significantly higher than that in the group A1 within 3,6 and 12 months(P<0.01);group A and group C were paired with 28 pairs,which were recorded as group A2 and group C2,the frequency of gout attacks in the group C2 was higher than that in the group A2 within 3,6 and 12 months(P<0.05 to P<0.01);group A and group D were paired with 13 pairs,which were recorded as group A3 and group D3,the frequency of gout attacks in the group D3 was significantly higher than that in the group A3 within 3,6 and 12 months(P<0.01).Conclusions:Elevated blood lipid level can increase the frequency of gout attacks.

关 键 词：痛风 胆固醇 三酰甘油 发病频率 

分 类 号：R58[医药卫生—内分泌]