微生物组学——子宫内膜异位症病因学研究新方向  

Microbiomics:A new direction in etiology of endometriosis

作　　者：马颖[1] 黄思霞 黄柳菁 蔡朝霞 马菘 梁晓珊 MA Ying;HUANG Sixia;HUANG Liujing;CAI Zhaoxia;MA Song;LIANG Xiaoshan(Department of Obstetrics and Gynecology,Zhujiang Hospital,Southern Medical University,Guangzhou 510282,China;不详)

机构地区：[1]南方医科大学珠江医院妇产医学中心,广州510282 [2]广州市荔湾区妇幼保健院妇产科,广州510375 [3]珠海市第五人民医院妇产科,广东珠海519055

出　　处：《实用医学杂志》2022年第24期3027-3031,共5页The Journal of Practical Medicine

基　　金：广东省自然科学基金(编号:2022A1515011880);广东省大学生创新创业训练计划(编号:S202112121053);南方医科大学科研启蒙计划(编号:B521ZJ0050)。

摘　　要：子宫内膜异位症(endometriosis,EM)是妇科常见病,发病率逐年升高,主要引起慢性盆腔痛、不孕等。EM病因不明、危害较大,由于缺乏针对病因的“治本”疗法,除根治性手术外,常规手术后复发率极高,绝经前的患者需长期用药预防复发,且EM缺乏早期无创诊断及监测病情变化的敏感指标。现有研究提示EM与体内微生物失调存在密切关系,本文探讨了微生物参与了EM发生的可能方式,肠道微生物可能通过干预脂代谢、雌激素代谢等途径参与EM的发病;微生物及相关的代谢产物可能作为EM早期无创诊断标志物;低脂少碳饮食、不饱和脂肪酸摄入和补充益生菌等方式,可能成为防治EM的新方法。Endometriosis(EM)is a common gynecological disease with an increasing incidence yearly.It mainly causes chronic pelvic pain and infertility.Due to the lack of“root cause”therapy for the etiology,the recurrence rate after conventional surgery is very high except radical surgery.Premenopausal patients need long-term medication to prevent its recurrence.Moreover,there is no sensitive index for its early non-invasive diagnosis and monitoring of its early changes.Existing studies suggest that EM is closely related with microbial dysregulation in vivo.In this paper,we exploredthe possible ways by which microorganisms participate in the occurrence of EM.We concluded by reviewing literature that intestinal microorganisms may participate in the pathogenesis of EM by intervening lipid metabolism,estrogen metabolism and other ways,microorganisms and related metabolites may be used as early noninvasive diagnostic markers for EM,and finally,low fat and low carbon diet,consumingunsaturated fatty acids and probiotics supplementation may be a new approach to the prevention and control of EM.

关 键 词：子宫内膜异位症 微生物 代谢产物 发病机制 治疗 

分 类 号：R711.71[医药卫生—妇产科学]