腹腔内应用罗哌卡因对腹腔镜手术后加速康复的研究进展  

Research progress of intraperitoneal administration of ropivacaine for enhanced recovery after laparoscopic surgery

作　　者：冷世泽 张辉[1,2] LENG Shize;ZHANG Hui(Ji'nan University,Guangzhou 510632,China;Guangdong Second Provincial General Hospital,Guangzhou 510317,China;不详)

机构地区：[1]暨南大学,广州510632 [2]广东省第二人民医院,广州510317

出　　处：《实用医学杂志》2022年第24期3162-3166,共5页The Journal of Practical Medicine

基　　金：广东省中医药局科研项目(编号:20221017)。

摘　　要：腹腔镜手术后疼痛以及恶心呕吐等不良事件严重影响患者的术后康复,因此良好的术后镇痛及减少术后并发症是加速康复外科的重要目标。罗哌卡因作为一种长效的酰胺类局麻药,不仅可阻断神经兴奋与传导,还具有抗炎、抑制细胞损伤和抗癌等效果。腹腔内应用罗哌卡因可减轻术后疼痛与应激水平;减少恶心呕吐发生率;促进胃肠功能恢复,有利于腹腔镜手术后加速康复。本文将对围术期腹腔内应用罗哌卡因的临床效果、可能机制、安全性及用药策略进行综述。Pain,nausea and vomiting,and other adverse events after laparoscopic surgery seriously affect the recovery of patients.Therefore,seeking better analgesia and effectively reducing postoperative complications are important goals in enhance recovery after surgery.As a long-term amide local anesthetic,ropivacaine can not only block nerve excitation and conduction,but also has the effects of anti-inflammation,inhibition of cell injury and anti-cancer.Intraperitoneal administration of ropivacaine can reduce postoperative pain and surgical stress levels;reduce the incidence of nausea and vomiting,and promote gastrointestinal function recovery.It is conducive to accelerating postoperative rehabilitation.This review summarizes the clinical effects,possible mechanisms,safety,and administration strategies of intraperitoneal administration of ropivacaine.

关 键 词：罗哌卡因 腹腔镜 腹腔内 围手术期 加速术后康复 

分 类 号：R614.1[医药卫生—麻醉学]