药物性肝损伤中miR-122的动态表达研究进展  

Research progress on dynamic expression of miR-122 in drug-induced liver injury

作　　者：李娟娟 何婷 魏亚利 雷源 古巧燕[1] LI Juanjuan;HE Ting;WEI Yali;LEI Yuan;GU Qiaoyan(Department of Gastroenterology,Affiliated Hospital of Yan'an University,Yan'an 716000,China)

机构地区：[1]延安大学附属医院消化内科,陕西延安716000

出　　处：《实用医学杂志》2022年第24期3167-3170,共4页The Journal of Practical Medicine

基　　金：陕西省留学人员科技活动择优资助项目(编号:2020014)。

摘　　要：药物性肝损伤(DILI)是一种最常见和最严重的药物不良反应之一,临床上因缺乏特异性标志物而很难确诊。许多研究报道miR-122是肝毒性潜在的生物标志物,因此本文叙述了DILI中miR-122表达的时程变化、miR-122与DILI的肝再生与修复过程的相关性以及miR-122表达水平与肝组织病理损伤程度的对应关系,旨在总结miR-122的动态表达规律,从而服务临床。Drug-induced liver injury(DILI)is one of the most common and serious adverse drug reactions,which is difficult to diagnose clinically due to the lack of specific markers.Many studies have reported that miR-122 is a potential biomarker of hepatotoxicity.Therefore,this paper describes the temporal changes of miR-122 expression in DILI,the correlation between miR-122 and the liver regeneration and repair process of DILI,and the correspondence between miR-122 expression level and the degree of liver histopathological damage,aiming to summarize the dynamic expression pattern of miR-122.

关 键 词：药物性肝损伤 MIR-122 动态表达 

分 类 号：R99[医药卫生—毒理学]