靶向脂质体的药理学评价  

Pharmacological evaluation of targeting liposomes

作　　者：王富喜 邓宏图(综述) 王滨(审校)[1] WANG Fuxi;DENG Hongtu;WANG Bin(Department of Pharmacy,Affiliated Hospital of Binzhou Medical College,Binzhou,Shandong 256600,China)

机构地区：[1]滨州医学院附属医院药学部,山东滨州256600

出　　处：《现代医药卫生》2023年第1期137-140,共4页Journal of Modern Medicine & Health

摘　　要：与传统制剂相比,靶向脂质体成为新药研发的热点,其可提高药物的选择性,提高疗效同时减少不良反应,改善患者的顺应性。针对靶向脂质体进行科学规范的药理学评价,对保证药物制剂的安全、有效及质量可控具有重要意义。本文综述了靶向脂质体临床前的药理评价,以靶向脂质体质量研究与控制为参考,着重阐述靶向脂质体药理学评价的技术和方法。Compared with traditional preparations, the targeted liposomes have become a hot spot in the development of new drugs, which can improve the drug selectivity, increase the efficacy, reduce the adverse reactions and improve the patient compliance.Conducting the scientific and standardized pharmacological evaluation on targeted liposomes is of great significance to ensure the safety, efficacy and quality control of pharmaceutical preparations.This paper reviews the preclinical pharmacological evaluation of targeted liposomes.Taking the quality research and control of targeted liposomes as reference, it focuses on the technology and method of pharmacological evaluation of targeted liposomes.

关 键 词：靶向制剂 活体荧光成像 流式细胞术 综述 

分 类 号：R965[医药卫生—药理学]