左甲状腺素钠片治疗妊娠期亚临床甲状腺功能减退的有效性及其对新生儿行为的影响  

Effectiveness of levothyroxine sodium tablets in pregnancy patients with subclinical hypothyroidism and its influence on behavior of newborn

作　　者：赵雅玲[1] 黎海龙[1] ZHAO Ya-ling;LI Hai-long(Dongguan Chang'an Hospital,Dongguan 523843,China)

机构地区：[1]东莞市长安医院,广东东莞523843

出　　处：《中国药物应用与监测》2022年第6期363-366,共4页Chinese Journal of Drug Application and Monitoring

摘　　要：目的:探讨左甲状腺素钠片治疗妊娠期亚临床甲状腺功能减退(甲减)的有效性及其对新生儿行为能力的影响。方法:采用前瞻性研究方法,选取2020年1月–2021年2月我院亚临床甲减孕妇96例,按照随机数字表法分为试验组和对照组,每组各48例,分别给予左甲状腺素钠片和甲状腺片治疗。对比两组甲状腺功能(TSH、TGAb、TRAb水平)、临床疗效、妊娠结局以及对新生儿行为的影响。结果:与治疗前相比,治疗后两组孕妇的TSH、TGAb、TRAb水平均降低(P<0.05),且试验组较对照组降低更明显(P<0.05)。试验组治疗总有效率(95.83%)显著高于对照组(70.83%),P<0.05;试验组自然分娩率(72.92%)显著高于对照组(39.58%),P<0.05。两组新生儿早产、胎儿窘迫、胎儿窒息发生率差异不明显(P>0.05)。两组新生儿的对光及声音习惯形成、对说话人脸反应等评分比较差异有统计学意义(P<0.05)。此外,试验组不良反应总发生率(4.17%)明显低于对照组(14.59%),P<0.05。结论:左甲状腺素钠片能够有效降低妊娠期亚临床甲减孕妇的血清TSH、TGAb、TRAb水平,并有效改善患者的妊娠结局和新生儿的行为能力,减少不良反应发生率。Objective:To explore the effectiveness of levothyroxine sodium tablets in pregnancy patients with subclinical hypothyroidism and its influence on behavior of newborn.Methods:96 pregnant women with subclinical hypothyroidism in our hospital from January 2020 to February 2021 were perspectively selected and divided into the experimental group(n=48)and the control group(n=48)according to the random number table method.Levothyroxine sodium tablets and thyroid tablets were given to the experimental group and the control group respectively.Thyroid function(TSH,TGAb,TRAb levels),clinical efflcacy,pregnancy outcomes and changes in neonatal behavior were compared between the two groups.Results:After treatment,the levels of TSH,TGAb and TRAb in patients were all obviously reduced(P<0.05),among which those of the experimental group were lower than those of the control group(P<0.05).The total effective rate and the natural delivery rate in the experimental group were significantly higher than those of the control group(95.83%vs 70.83%,72.92%vs 39.58%),P<0.05.There were no differences in premature birth,fetal distress,and fetal asphyxia between the two groups(P>0.05).There were significant differences in the scores of newborns formation of light and sound habits,reaction to the face of the speaker between the two groups(P<0.05).And the incidence of adverse drug reaction in the experimental group(4.17%)was significantly lower than that of the control group(14.59%),P<0.05.Conclusion:Levothyroxine sodium tablets could effectively reduce the serum levels of TSH,TGAb,TRAb in pregnancy women with subclinical hypothyroidism,improve their pregnancy outcome and the behavioral ability of the newborn,and reduce the incidence of adverse drug reactions.

关 键 词：甲状腺功能 妊娠期 行为能力 左甲状腺素钠 亚临床甲状腺功能减退 

分 类 号：R969.4[医药卫生—药理学] R977.14[医药卫生—药学]